INT201683

Context Info Confidence 0.80 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 18 Disease Relevance 6.60 Pain Relevance 2.01

Anatomy Link Frequency neurons 1 GSK (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 120 98.40 Eae 10 92.64 diabetic neuropathy 53 87.84 unmyelinated 2 84.72 Hippocampus 31 79.20 agonist 5 77.28 Inflammation 88 76.68 withdrawal 2 76.48 Central nervous system 37 75.44 cytokine 52 59.12

Disease Link Frequency Relevance Heat Stress 100 100.00 Thyroid Neoplasm 161 99.42 Apoptosis 252 99.40 Diabetes Mellitus 171 98.96 Necrosis 8 98.92 Parkinson's Disease 16 98.44 Bladder Cancer 128 96.60 Death 83 96.48 Infection 62 96.08 Targeted Disruption 60 95.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In cortical neurons ceramide induces activation of the mitochondrial apoptotic cascade and is associated to dephosphorylation of Akt, BAD, FKH and GSK-3?

Phosphorylation (dephosphorylation) of GSK in neurons associated with apoptosis

1) Confidence 0.80 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.42 Pain Relevance 0.04

At our institution, Kunnimalaiyaan et al (2007b) found that raf-1 activation in human MTC cells (TT cells) results in phosphorylation of GSK-3?

Phosphorylation (phosphorylation) of GSK associated with thyroid neoplasm

2) Confidence 0.80 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.58 Pain Relevance 0

Although this pattern was not seen for the changes in phosphorylation of mTOR, 4E-BP1, and GSK-3?

Phosphorylation (phosphorylation) of GSK

3) Confidence 0.80 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

The phosphorylation of PKB Ser473 and p70S6k Thr389 increased concomitantly with insulin, but whereas raising insulin to 30 mU/l increased the phosphorylation of mTOR Ser2448, 4E-BP1 Thr37/46, or GSK3?

Phosphorylation (phosphorylation) of GSK

4) Confidence 0.80 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Abstract Doc Link PMC2536736 Disease Relevance 0.09 Pain Relevance 0

Tau is normally phosphorylated by GSK-3?

Phosphorylation (phosphorylated) of GSK

5) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.04 Pain Relevance 0.04

Although the exact mechanism of PPF is unknown, it reduced the active form of GSK-3?

Phosphorylation (form) of GSK

6) Confidence 0.79 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.33 Pain Relevance 0.04

upregulation of phosphorylating stress kinases like SAPK and GSK-3?

Phosphorylation (phosphorylating) of GSK associated with stress

7) Confidence 0.79 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.70 Pain Relevance 0.19

In addition, the SO group had 63% higher levels of phosphorylated GSK3?

Phosphorylation (phosphorylated) of GSK

8) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.31 Pain Relevance 0.13

tyr216 phosphorylation without inhibiting GSK3?

Phosphorylation (phosphorylation) of GSK

9) Confidence 0.61 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.24 Pain Relevance 0.11

ser9, with subsequently decreased phosphorylation of the GSK3?

Phosphorylation (phosphorylation) of GSK

10) Confidence 0.61 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.28 Pain Relevance 0

The mechanism for this inhibition involves regulating phosphorylation of specific cell signaling molecules (Akt, GSK3?

Phosphorylation (phosphorylation) of GSK

11) Confidence 0.61 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC3020166 Disease Relevance 0.17 Pain Relevance 0.03

Therefore, the decreased phosphorylation of GSK-3?

Phosphorylation (phosphorylation) of GSK

12) Confidence 0.61 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.00 Pain Relevance 0.11

Phosphorylation of GSK-3?

Phosphorylation (Phosphorylation) of GSK

13) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.58 Pain Relevance 0.69

We investigated the effect of TLR9 on phosphorylation of GSK-3?

Phosphorylation (phosphorylation) of GSK

14) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.53 Pain Relevance 0.63

The phosphorylation based inactivation of GSK3?

Phosphorylation (phosphorylation) of GSK

15) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0

Fig. 1E shows the phosphorylation status of the Akt substrate GSK-3?

Phosphorylation (phosphorylation) of GSK

16) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.16 Pain Relevance 0

Furthermore, LiCl has been shown to stimulate Akt which phosphorylates and inhibits GSK3?

Phosphorylation (phosphorylates) of GSK

17) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0

ser9 phosphorylation, but a substantial decrease in GSK3?

Phosphorylation (phosphorylation) of GSK

18) Confidence 0.61 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.17 Pain Relevance 0

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