INT201691

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2)
cytoplasm (RIPK2) signal transducer activity (RIPK2)
RIPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 99.78 Very High Very High Very High
withdrawal 3 76.96 Quite High
anakinra 19 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 99.78 Very High Very High Very High
Disease 147 98.62 Very High Very High Very High
Syndrome 113 90.44 High High
Apoptosis 134 88.92 High High
Exanthema 7 86.92 High High
Arthralgia 5 86.48 High High
Fever 8 85.08 High High
Brain Injury 1 54.64 Quite High
Death 58 37.84 Quite Low
Toxicity 15 8.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
as the principal consequence of CIAS1 mutations leading to the manifestation of the clinical disease, the CASP1 mutation appears to exert its pro-inflammatory effect by engaging RIP2, resulting in excessive activation of NF-?
RIP2 Binding (engaging) of associated with inflammation and disease
1) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.09 Pain Relevance 0.13
Recently, in vitro studies have shown that NF-kB activation can be mediated by the interaction of p75 with RIP2 and TRAF-6 [160,161].
RIP2 Binding (mediated) of
2) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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