INT201693

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
cleavage 2
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 12 71.12 Quite High
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 64 99.32 Very High Very High Very High
Toxicity 30 98.90 Very High Very High Very High
Disease 254 96.52 Very High Very High Very High
Death 112 96.44 Very High Very High Very High
Neurodegenerative Disease 72 66.32 Quite High
Apoptosis 266 63.16 Quite High
Aging 10 55.84 Quite High
Diabetes Mellitus 2 30.48 Quite Low
Increased Venous Pressure Under Development 2 23.80 Low Low
Hyperlipidemia 2 11.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
- toxicity and oxidative stress [152] by a mechanism mediated by reduced PI3K/Akt signaling and JNK/p53 activation, thus providing a link between NGF deprivation and the two pathological components of AD.
Negative_regulation (reduced) of Positive_regulation (activation) of PI3K associated with stress, toxicity and disease
1) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.72 Pain Relevance 0.04
due to downregulation of PI3K/Akt, as well as by activation of the p25-cdk5 complex following Ca2+-dependent activation of calpains and cleavage of p35, and both pathways can become synergistically activated upon trophic factors deprivation and ROS accumulation, suggesting that cells use more than one route to respond to stimuli.
Negative_regulation (downregulation) of Positive_regulation (activation) of PI3K in cleavage
2) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.31 Pain Relevance 0

General Comments

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