INT201694

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
cleavage 2
PSEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 5 77.76 Quite High
Hippocampus 10 76.88 Quite High
bradykinin 75 54.96 Quite High
antagonist 3 27.24 Quite Low
gABA 1 26.40 Quite Low
Eae 9 19.00 Low Low
Inflammation 40 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Generaliased Trisomy 2 98.64 Very High Very High Very High
Disease 473 98.40 Very High Very High Very High
Syndrome 15 98.08 Very High Very High Very High
Death 65 77.60 Quite High
Amyloid Plaque 16 73.28 Quite High
Congenital Anomalies 3 70.28 Quite High
Targeted Disruption 35 67.92 Quite High
Aging 10 64.16 Quite High
Alzheimer's Dementia 28 58.24 Quite High
Apoptosis 168 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
42 is constitutively produced in the brain, mutations in the APP or PS1/2 genes (which alter the cleavage specificity of ?
Negative_regulation (/) of Gene_expression (mutations) of PS1 in cleavage
1) Confidence 0.41 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.41 Pain Relevance 0.08
DownÂ’s syndrome (DS) patients, who are trisomic for chromosome 21 and thus have an extra copy of the APP gene, and FAD families with a duplicated APP gene locus [4] exhibit total A?
Negative_regulation (exhibit) of Gene_expression (families) of FAD associated with syndrome and generaliased trisomy
2) Confidence 0.41 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.43 Pain Relevance 0
The site-specific differences in BKB2R signal strength we observe parallel the degree to which the PS-1 mutation is an aggressive one, reflected in both an earlier age of onset of the disease and in secretion of A?
Negative_regulation (reflected) of Gene_expression (mutation) of PS-1 associated with disease
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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