INT201731

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Akt1, Cdk5) plasma membrane (Akt1, Cdk5) cytoplasm (Akt1, Cdk5)
cytosol (Akt1, Cdk5) kinase activity (Akt1, Cdk5) transport (Akt1)
Anatomy Link Frequency
cleavage 2
Akt1 (Mus musculus)
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 56 77.84 Quite High
Neurodegenerative Disease 36 66.32 Quite High
Stress 32 51.88 Quite High
Apoptosis 133 50.00 Quite Low
Disease 127 50.00 Quite Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
due to downregulation of PI3K/Akt, as well as by activation of the p25-cdk5 complex following Ca2+-dependent activation of calpains and cleavage of p35, and both pathways can become synergistically activated upon trophic factors deprivation and ROS accumulation, suggesting that cells use more than one route to respond to stimuli.
Negative_regulation (downregulation) of Akt Binding (complex) of cdk5 in cleavage
1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox