INT201736

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1, Sod2) DNA binding (Nfkb1, Sod2) cytoplasm (Nfkb1, Sod2)
mitochondrion organization (Sod2) protein complex (Nfkb1) response to stress (Sod2)
Anatomy Link Frequency
nucleus 2
Nfkb1 (Mus musculus)
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 89.52 High High
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 133 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 4 84.52 Quite High
Death 56 80.12 Quite High
Stress 32 79.52 Quite High
Disease 127 58.88 Quite High
Neurodegenerative Disease 36 5.00 Very Low Very Low Very Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation and degradation of IkB, the inhibitory subunit that sequesters the NF-kB complex in the cytoplasm, releases NF-kB which can traslocate to the nucleus and activate the transcription of genes that promote resistance to apoptosis, such as MnSOD, Bcl-2 and members of the Inhibitor of Apoptosis Proteins (IAPs) family.
NF-kB Positive_regulation (activate) of Transcription (transcription) of MnSOD in nucleus associated with apoptosis
1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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