INT201738

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0

nucleus (Akt1, Cdk5) plasma membrane (Akt1, Cdk5) cytoplasm (Akt1, Cdk5) cytosol (Akt1, Cdk5) kinase activity (Akt1, Cdk5) transport (Akt1)

Anatomy Link Frequency cleavage 2 Akt1 (Mus musculus) Cdk5 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 9 5.00 cytokine 8 5.00 Hippocampus 7 5.00 Eae 6 5.00 long-term potentiation 5 5.00 Kinase C 5 5.00 Neurotransmitter 5 5.00 Central nervous system 4 5.00 Neuropeptide 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Death 56 76.92 Neurodegenerative Disease 36 65.40 Stress 32 50.96 Apoptosis 133 50.00 Disease 127 50.00 Cognitive Disorder 16 5.00 Toxicity 15 5.00 INFLAMMATION 13 5.00 Parkinson's Disease 8 5.00 Injury 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

due to downregulation of PI3K/Akt, as well as by activation of the p25-cdk5 complex following Ca2+-dependent activation of calpains and cleavage of p35, and both pathways can become synergistically activated upon trophic factors deprivation and ROS accumulation, suggesting that cells use more than one route to respond to stimuli.

Positive_regulation (activated) of Akt Binding (complex) of cdk5 in cleavage

1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.31 Pain Relevance 0

General Comments

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