INT201747

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Itpr3, Esr1) nucleus (Itpr3, Esr1) nucleoplasm (Itpr3)
transport (Itpr3) endoplasmic reticulum (Itpr3) enzyme binding (Esr1)
Anatomy Link Frequency
reticulum 2
Itpr3 (Mus musculus)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 99.52 Very High Very High Very High
Inflammatory response 13 14.04 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 108 89.84 High High
Apoptosis 161 89.80 High High
Frailty 24 82.88 Quite High
Targeted Disruption 15 78.84 Quite High
Stress 68 73.76 Quite High
Drug Induced Neurotoxicity 4 67.04 Quite High
Disease 128 50.00 Quite Low
Diabetes Mellitus 10 41.84 Quite Low
Pancreatitis 22 40.40 Quite Low
Congenital Anomalies 3 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of exogenously supplied IP3 to induce ER Ca2+ release was also normal.
IP3 Positive_regulation (induce) of Localization (release) of ER Ca2
1) Confidence 0.03 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.53 Pain Relevance 0
and production of two intracellular second messenger: diacylglycerol (DAG), a potent activator of PKC, and Inositol 1,4,5-P3(IP3) which stimulates the release of Ca2+ from the endoplasmic reticulum (ER) and the activity of Ca2+-dependent proteins (Ca2+-calmodulin protein kinase) and phosphatases.
IP3 Positive_regulation (stimulates) of Localization (release) of ER in reticulum associated with kinase c
2) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.65 Pain Relevance 0.09

General Comments

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