INT201748

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Cdk5r1) lyase activity (Car2) embryo development (Cdk5r1)
cytosol (Car2) cytoskeletal protein binding (Cdk5r1) extracellular space (Car2)
Car2 (Mus musculus)
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 98.76 Very High Very High Very High
Kinase C 5 85.56 High High
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 56 99.96 Very High Very High Very High
Stress 32 95.48 Very High Very High Very High
Apoptosis 133 75.44 Quite High
Disease 127 70.24 Quite High
Neurodegenerative Disease 36 54.08 Quite High
Aging 5 50.88 Quite High
Toxicity 15 45.88 Quite Low
Drug Induced Neurotoxicity 4 41.40 Quite Low
Amyloid Plaque 5 35.60 Quite Low
Injury 7 19.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides the role in cell death, Ca2+ gives a further contribution to the formation of NFT by activating calpains and p25-cdk5 complexes which increase tau phosphorylation [188,189].
Ca2 Positive_regulation (activating) of p25 associated with eae and death
1) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.67 Pain Relevance 0.09

General Comments

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