INT201759

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.84 Pain Relevance 0

cytosol (PIK3CG) signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf) plasma membrane (PIK3CG) cytoplasm (PIK3CG)

Anatomy Link Frequency Fibroblast 1 Ngf (Mus musculus) PIK3CG (Homo sapiens)

Pain Link Frequency Relevance Heat Eae 6 30.88 Inflammation 9 5.00 cytokine 8 5.00 Hippocampus 7 5.00 long-term potentiation 5 5.00 Kinase C 5 5.00 Neurotransmitter 5 5.00 Central nervous system 4 5.00 Neuropeptide 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Disease 127 92.36 Apoptosis 133 83.24 Stress 32 77.84 Aging 5 75.92 Death 56 71.20 Toxicity 15 68.72 Diabetes Mellitus 1 50.56 Increased Venous Pressure Under Development 1 43.88 Hyperlipidemia 1 32.00 Disorder Of Lipid Metabolism 1 26.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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is phosphorylated (and inactivated) through a PI3K/Akt signaling pathway induced by IGF-1, NGF and any growth factor whose activity is mediated by receptors with intrinsic tyrosine kinase activity [201], including also Fibroblast Growth Factor-2 (FGF-2).

NGF Positive_regulation (induced) of PI3K in Fibroblast

1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.84 Pain Relevance 0

General Comments

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