INT20176

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Context Info
Confidence 0.72
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 21
Disease Relevance 7.32
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
lactotrophs 3
anterior pituitary 2
thyroid 1
pituitary 1
pituitary stalk 1
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 42 99.90 Very High Very High Very High
cryotherapy 5 99.68 Very High Very High Very High
Dismenorea 1 99.54 Very High Very High Very High
agonist 28 99.36 Very High Very High Very High
Opioid 5 94.48 High High
Dopamine 30 93.20 High High
headache 2 93.20 High High
Endogenous opioid 4 92.56 High High
Pain 3 91.36 High High
Kappa opioid receptor 3 91.00 High High
Disease Link Frequency Relevance Heat
Prolactinoma 29 99.96 Very High Very High Very High
Coronary Artery Disease 126 99.72 Very High Very High Very High
Stress 63 98.84 Very High Very High Very High
Cancer 35 98.40 Very High Very High Very High
Reprotox - General 1 2 96.36 Very High Very High Very High
Drug Dependence 1 96.28 Very High Very High Very High
Disease 3 95.52 Very High Very High Very High
Prostate Cancer 3 94.68 High High
Galactorrhea 7 93.28 High High
Headache 2 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: (1) Blockade of progesterone action by mifepristone activated the lactotrope, increased significantly prolactin mRNA and protein expression and prepared the pituitary for naloxone action. (2) The high serum prolactin levels induced by mifepristone and naloxone may regulate negatively lactotrope activity as suggested by the presence of regressing cells neighboring the actively secreting cells.


Transcription (expression) of prolactin in lactotrope
1) Confidence 0.72 Published 2009 Journal Neuroendocrinology Section Body Doc Link 18832805 Disease Relevance 0 Pain Relevance 0
Mifepristone increased prolactin mRNA and protein expression.
Transcription (expression) of prolactin
2) Confidence 0.72 Published 2009 Journal Neuroendocrinology Section Body Doc Link 18832805 Disease Relevance 0 Pain Relevance 0
Estrogens stimulate PRL gene transcription via at least two independent mechanisms.
Transcription (transcription) of PRL gene
3) Confidence 0.70 Published 1990 Journal Klin. Wochenschr. Section Abstract Doc Link 2126309 Disease Relevance 0.63 Pain Relevance 0.14
In contrast, there were no changes in the levels of mRNA coding for PRL in the adenohypophysis.
Transcription (coding) of PRL in adenohypophysis
4) Confidence 0.68 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.46 Pain Relevance 0.09
In E(2)-induced rat prolactinomas, prolactin mRNA contents and the expression of some proto-oncogenes, e.g. c-myc and c-ras, TGFalpha and TGFbeta1 mRNA were significantly changed.
Transcription (expression) of prolactin mRNA associated with prolactinoma
5) Confidence 0.67 Published 2000 Journal Biol Signals Recept Section Abstract Doc Link 10686432 Disease Relevance 0.83 Pain Relevance 0.21
Maternal prolactin levels were not predictive of any complications.
Neg (not) Transcription (predictive) of prolactin
6) Confidence 0.67 Published 1983 Journal Obstet Gynecol Section Abstract Doc Link 6888819 Disease Relevance 0.45 Pain Relevance 0.09
[Gynaecological use of prolactin inhibitor bromocriptin (author's transl)].
Transcription (bromocriptin) of prolactin associated with dismenorea
7) Confidence 0.66 Published 1981 Journal Zentralbl Gynakol Section Title Doc Link 7202312 Disease Relevance 0.19 Pain Relevance 0.10
These results show that exogenous E-cadherin does not affect prolactin mRNA transcription; rather, it decreases the protein content of prolactin.
Transcription (transcription) of prolactin
8) Confidence 0.55 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.38 Pain Relevance 0
In contrast, in rE-cad-IZ-transfected cells (indicated by the arrows in Fig. 2), prolactin mRNA signals (Fig. 2D and 2H) were detected, but prolactin immunoreactivity (Fig. 2C and 2F) was barely detectable.
Transcription (signals) of prolactin associated with coronary artery disease
9) Confidence 0.53 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.43 Pain Relevance 0
Prolactin immunoreactivities and mRNA signals in hormone-producing cells expressing E-cadherin
Transcription (immunoreactivities) of Prolactin
10) Confidence 0.53 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.43 Pain Relevance 0
The employed stress paradigm also induced an elevation of anterior pituitary levels of PRL and POMC mRNAs.
Transcription (levels) of PRL in anterior pituitary associated with stress
11) Confidence 0.53 Published 1994 Journal Peptides Section Abstract Doc Link 7984495 Disease Relevance 0.62 Pain Relevance 0.41
The variations of prolactin levels before and after therapy (p=0.49) as well as the percentage of prolactin normalization (p=0.20) did not show any significant difference when comparing the two groups.
Transcription (levels) of prolactin
12) Confidence 0.51 Published 2003 Journal Arq Neuropsiquiatr Section Abstract Doc Link 14762607 Disease Relevance 0.59 Pain Relevance 0.17
Serum LH, prolactin and testosterone levels in Copenhagen F-1 rats bearing Dunning tumors were significantly decreased after treatment with D-Trp6-LH-RH.
Transcription (levels) of prolactin associated with cancer
13) Confidence 0.44 Published 1984 Journal Med Oncol Tumor Pharmacother Section Abstract Doc Link 6242477 Disease Relevance 0.87 Pain Relevance 0
Using in situ hybridization and immunocytochemical techniques, we utilized lactotrophs to examine whether forced E-cadherin expression by gene transfection affects prolactin mRNA expression and prolactin production.


Transcription (expression) of prolactin in lactotrophs
14) Confidence 0.41 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.09 Pain Relevance 0.09
These results suggest that the expression of E-cadherin does not affect prolactin mRNA transcription; rather, it reduces prolactin protein content, presumably by affecting trafficking of secretory granules.



Transcription (transcription) of prolactin
15) Confidence 0.41 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2875860 Disease Relevance 0.30 Pain Relevance 0
The level of prolactin mRNA expression in rE-cad-IZ-transfected cells appeared similar to that in untransfected cells and null-IZ-transfected cells (Figs. 2 and 3).
Transcription (expression) of prolactin associated with coronary artery disease
16) Confidence 0.41 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.41 Pain Relevance 0
In the present study, we examined the roles of cadherin switching in cytogenesis of anterior pituitary cells by observing prolactin mRNA and protein expression in lactotrophs that were transformed with an E-cadherin expression vector.
Transcription (expression) of prolactin in lactotrophs
17) Confidence 0.41 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2875860 Disease Relevance 0.29 Pain Relevance 0
The effects of s.c. bremazocine and U50,488 (trans-(+/-)-3, 4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid e; agonists), nalorphine (partial agonist) and nalmefene (antagonist) on prolactin levels were studied in intact female rhesus monkeys.
Transcription (levels) of prolactin associated with antagonist and agonist
18) Confidence 0.35 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10594324 Disease Relevance 0 Pain Relevance 0.34
Other investigators also found N-POMC increases PRL and GH mRNA expression and stimulates PRL and GH secretion (after 12 h of treatment) in frog pituitary cell cultures (165).
Transcription (expression) of PRL in pituitary
19) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09
The aim of the present study was to examine the effects of two types of cold therapy, winter swimming in ice-cold water (WS) and whole body cryotherapy (WBC), on the serum levels of the growth hormone, prolactin, thyrotropin and free fractions of thyroid hormones (fT3, fT4).
Transcription (levels) of prolactin in thyroid associated with cryotherapy
20) Confidence 0.22 Published 2009 Journal Cryobiology Section Abstract Doc Link 19444973 Disease Relevance 0.27 Pain Relevance 0.37

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