INT201761

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.43 Pain Relevance 0

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax) cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)

BIK (Homo sapiens) Bax (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 9 5.00 cytokine 8 5.00 Hippocampus 7 5.00 Eae 6 5.00 long-term potentiation 5 5.00 Kinase C 5 5.00 Neurotransmitter 5 5.00 Central nervous system 4 5.00 Neuropeptide 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 133 95.16 Coronary Artery Disease 1 77.32 Death 56 59.92 Stress 32 57.84 Disease 127 50.00 Neurodegenerative Disease 36 5.00 Cognitive Disorder 16 5.00 Toxicity 15 5.00 INFLAMMATION 13 5.00 Parkinson's Disease 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bax and Bak activation is mediated by Bad, Bik, Bid, and Bim and is due to either the preferential interaction with Bcl-2 and Bcl-XL, or their release from these anti-apoptotic proteins, thus shifting the balance of the different heterodimers toward the formation of the proapoptotic Bax and Bak homodimers.

Bik Positive_regulation (mediated) of Positive_regulation (activation) of Bax associated with apoptosis

1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.43 Pain Relevance 0

General Comments

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