INT201770

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9, Apaf1) nucleus (CASP9, Apaf1) intracellular (CASP9, Apaf1)
peptidase activity (CASP9) Golgi apparatus (Apaf1) cytoplasm (Apaf1)
CASP9 (Homo sapiens)
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 68.68 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 8 93.72 High High
Apoptosis 133 90.80 High High
Disease 127 85.80 High High
Death 56 73.84 Quite High
Stress 32 71.76 Quite High
Toxicity 15 68.24 Quite High
Shock 1 49.12 Quite Low
Necrosis 3 40.60 Quite Low
Cancer 2 40.24 Quite Low
Neurodegenerative Disease 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Traslocation of Bax homodimers to mitochondria leads to release of cytochrome C to the cytosol and its binding to APAF-1 with formation of the apoptosome and recruitment of procaspase-9.
caspase-9 Binding (binding) of APAF-1
1) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.89 Pain Relevance 0.03

General Comments

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