INT201770

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.03

cytosol (CASP9, Apaf1) nucleus (CASP9, Apaf1) intracellular (CASP9, Apaf1) peptidase activity (CASP9) Golgi apparatus (Apaf1) cytoplasm (Apaf1)

CASP9 (Homo sapiens) Apaf1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 8 68.68 Inflammation 9 5.00 Hippocampus 7 5.00 Eae 6 5.00 long-term potentiation 5 5.00 Kinase C 5 5.00 Neurotransmitter 5 5.00 Central nervous system 4 5.00 Neuropeptide 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 8 93.72 Apoptosis 133 90.80 Disease 127 85.80 Death 56 73.84 Stress 32 71.76 Toxicity 15 68.24 Shock 1 49.12 Necrosis 3 40.60 Cancer 2 40.24 Neurodegenerative Disease 36 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Traslocation of Bax homodimers to mitochondria leads to release of cytochrome C to the cytosol and its binding to APAF-1 with formation of the apoptosome and recruitment of procaspase-9.

caspase-9 Binding (binding) of APAF-1

1) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.89 Pain Relevance 0.03

General Comments

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