INT20179

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Context Info
Confidence 0.54
First Reported 1989
Last Reported 2008
Negated 2
Speculated 0
Reported most in Title
Documents 12
Total Number 12
Disease Relevance 3.99
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
ovary 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 4 100.00 Very High Very High Very High
Sumatriptan 32 99.84 Very High Very High Very High
Clonidine 19 99.84 Very High Very High Very High
Dopamine 12 98.54 Very High Very High Very High
Opioid 4 97.12 Very High Very High Very High
Somatostatin 52 86.60 High High
monoamine 1 86.24 High High
alcohol 38 83.08 Quite High
opiate 1 81.16 Quite High
antagonist 2 80.52 Quite High
Disease Link Frequency Relevance Heat
Autism 2 99.96 Very High Very High Very High
Hypoglycemia 8 99.52 Very High Very High Very High
Obesity 14 98.88 Very High Very High Very High
Eating Disorder 7 98.56 Very High Very High Very High
Polycystic Ovary Syndrome 5 98.56 Very High Very High Very High
Diabetes Mellitus 9 97.96 Very High Very High Very High
Hypersensitivity 2 97.00 Very High Very High Very High
Hirsutism 1 85.84 High High
Anxiety Disorder 9 84.96 Quite High
Hypophysis Disease 5 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall GH control increased from 46% to 54% (Lucas et al 2006).
Positive_regulation (increased) of Regulation (control) of GH
1) Confidence 0.54 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.13 Pain Relevance 0
Growth hormone-releasing hormone pretreatment and all further stimuli elicited a statistically significant GH response in both obese and short-normal children; in the latter group arginine did not induce a significant GH response.
Neg (not) Positive_regulation (induce) of Neg (not) Regulation (response) of GH associated with obesity
2) Confidence 0.24 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7788012 Disease Relevance 0.58 Pain Relevance 0.31
Enhancement of the GH responsiveness to GH releasing stimuli by lysine vasopressin in type 1 diabetic subjects.
Positive_regulation (Enhancement) of Regulation (responsiveness) of GH associated with diabetes mellitus
3) Confidence 0.23 Published 1999 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 10583317 Disease Relevance 0.10 Pain Relevance 0.13
Enhancement of the GH responsiveness to GH releasing stimuli by lysine vasopressin in type 1 diabetic subjects.
Positive_regulation (Enhancement) of Regulation (responsiveness) of GH associated with diabetes mellitus
4) Confidence 0.23 Published 1999 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 10583317 Disease Relevance 0.10 Pain Relevance 0.13
Effects of naloxone on prolactin, growth hormone and cortisol response to insulin hypoglycemia in obese subjects.
Positive_regulation (response) of Regulation (Effects) of growth hormone associated with hypoglycemia, obesity and narcan
5) Confidence 0.22 Published 1989 Journal J. Endocrinol. Invest. Section Title Doc Link 2693516 Disease Relevance 0.76 Pain Relevance 0.59
CONCLUSIONS: These data show that in diabetic, but not in normal subjects LVP enhances the GH responsiveness to secretagogues, such as GH-RH, clonidine and arginine, which act through three different mechanisms.
Neg (not) Positive_regulation (enhances) of Regulation (responsiveness) of GH
6) Confidence 0.21 Published 1999 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 10583317 Disease Relevance 0 Pain Relevance 0
The administration of GH-RH (at the minimal dose), arginine or clonidine alone induced significantly higher GH responses in the diabetic subjects than in the normal controls.
Positive_regulation (induced) of Regulation (responses) of GH
7) Confidence 0.21 Published 1999 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 10583317 Disease Relevance 0.06 Pain Relevance 0
In contrast, the administration of GHRH, clonidine or insulin induced significant GH responses in all subjects.
Positive_regulation (induced) of Regulation (responses) of GH associated with clonidine
8) Confidence 0.20 Published 1990 Journal Neuropsychobiology Section Abstract Doc Link 2126361 Disease Relevance 0.74 Pain Relevance 0.33
In autism, increased GH response to sumatriptan was noted [14], with the severity of repetitive behaviours correlating with response.
Positive_regulation (increased) of Regulation (response) of GH associated with sumatriptan and autism
9) Confidence 0.20 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1208916 Disease Relevance 0.37 Pain Relevance 0.98
The peak GH response was significantly higher during the PD+GHRH test than during the ITT (P = 0.008).
Positive_regulation (higher) of Regulation (response) of GH
10) Confidence 0.18 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770183 Disease Relevance 0.28 Pain Relevance 0.21
The DA system of B subjects was found unimpaired; in contrast, a significantly higher GH response to brom in A subjects (depressed) could express D2 post-synaptic receptor hypersensitivity and, therefore, decreased pre-synaptic DA release.
Positive_regulation (higher) of Regulation (response) of GH associated with dopamine and hypersensitivity
11) Confidence 0.13 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084218 Disease Relevance 0.30 Pain Relevance 0.40
Influence of leptin, androgens and insulin sensitivity on increased GH response to clonidine in lean patients with polycystic ovary syndrome.
Positive_regulation (increased) of Regulation (response) of GH in ovary associated with polycystic ovary syndrome and clonidine
12) Confidence 0.01 Published 2005 Journal Horm. Metab. Res. Section Title Doc Link 15778926 Disease Relevance 0.57 Pain Relevance 0.32

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