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Context Info
Confidence 0.44
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Adcyap1r1) endosome (Adcyap1r1) plasma membrane (Adcyap1r1)
cytoplasm (Adcyap1r1) signal transducer activity (Adcyap1r1)
Anatomy Link Frequency
cortex 1
Adcyap1r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 1 94.72 High High
intrathecal 1 90.72 High High
Serotonin 1 86.00 High High
fluoxetine 2 83.68 Quite High
Inflammatory response 6 83.60 Quite High
Nerve growth factor 1 66.08 Quite High
Spinal cord 17 56.08 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 29 87.76 High High
INFLAMMATION 14 83.24 Quite High
Frailty 2 74.84 Quite High
Injury 35 45.12 Quite Low
Death 12 42.48 Quite Low
Apoptosis 24 32.16 Quite Low
Spinal Injuries 8 5.00 Very Low Very Low Very Low
Ganglion Cysts 7 5.00 Very Low Very Low Very Low
Contusions 6 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found the simultaneous down-regulation of three out of the four receptors of the GDNF family (Gfra1, Gfra2, Gfra3), as well as the down regulation of Ntrk1 (TrkA) and the Adcyap1r1 receptor.
Regulation (regulation) of Adcyap1r1
1) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.30 Pain Relevance 0.15
Chronic administration of the norepinephrine (NE) reuptake inhibitor nisoxetine reduced the sensitivity of the NE receptor-coupled adenylate cyclase system in rat cortex.
Regulation (sensitivity) of NE receptor-coupled adenylate cyclase in cortex
2) Confidence 0.26 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 316774 Disease Relevance 0 Pain Relevance 0.25

General Comments

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