INT201810

Context Info Confidence 0.56 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.94 Pain Relevance 1.74

extracellular space (LEFTY2) extracellular region (LEFTY2)

Anatomy Link Frequency macrophages 1 osteoblasts 1 skeletal muscle 1 LEFTY2 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 87 99.80 Inflammatory mediators 6 99.76 fibrosis 60 99.20 cytokine 61 98.20 Antinociceptive 3 94.72 Osteoarthritis 40 93.20 Arthritis 30 92.96 Inflammation 128 92.72 Analgesic 3 77.28 cINOD 6 74.96

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 87 99.80 INFLAMMATION 140 99.36 Pulmonary Fibrosis 41 99.20 Arthritis 23 93.88 Osteoarthritis 40 93.20 Experimental Arthritis 13 92.96 Hemorrhage 3 90.76 Fibrosis 42 86.80 Cancer 16 78.96 Chronic Disease 2 76.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

EBAF stimulates expression proMMP-3 and -7 in proliferative phase human endometrial explants, and P inhibits this as well as inhibition of EBAF expression [46].

Gene_expression (expression) of EBAF

1) Confidence 0.56 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.09 Pain Relevance 0.03

express different transforming growth factor-beta (TGF-?)

Gene_expression (express) of transforming growth factor-beta

2) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.14 Pain Relevance 0.44

The levels of alkaline phosphatase, osteocalcin, type I collagen, interleukin (IL)-6, transforming growth factor-beta, prostaglandin E2 (PGE2), leukotriene B4, and proteases, including urokinase, cathepsin K, and the metalloprotease (MMP)-13, have all been found to be elevated in human OA subchondral bone osteoblasts [6,9-13].

Gene_expression (levels) of transforming growth factor-beta in osteoblasts associated with osteoarthritis

3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 1.09 Pain Relevance 0.59

Moreover, this latex also increased NO and TNF-alpha and decreased transforming growth factor-beta (TGF-beta) production in macrophages.

Gene_expression (production) of transforming growth factor-beta in macrophages

4) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.46 Pain Relevance 0.21

PF was induced in rats by adenoviral gene transfer of transforming growth factor-beta.

Gene_expression (transfer) of transforming growth factor-beta associated with fibrosis

5) Confidence 0.03 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2365932 Disease Relevance 1.09 Pain Relevance 0.47

In general, studies that have compared the expression of MRFs such as myogenic determination factor (myoD), myogenic regulatory factor 5, and myogenin in rats have found that expression of these factors is decreased in older compared to younger skeletal muscle [51].

Gene_expression (expression) of myogenic determination factor in skeletal muscle

6) Confidence 0.02 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.06 Pain Relevance 0

General Comments

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