INT201846

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.74
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SFRP4) extracellular space (SFRP4) extracellular region (SFRP4)
nucleus (SFRP4) embryo development (SFRP4) cytoplasm (SFRP4)
Anatomy Link Frequency
endometrium 2
fallopian tubes 1
SFRP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 276 99.76 Very High Very High Very High
Inflammation 21 92.24 High High
antagonist 4 92.08 High High
cytokine 15 82.32 Quite High
metalloproteinase 37 5.00 Very Low Very Low Very Low
pain pelvic 7 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 393 99.76 Very High Very High Very High
Endometroid Carcinoma 21 96.76 Very High Very High Very High
INFLAMMATION 24 92.24 High High
Carcinoma 61 90.16 High High
Endometrial Cancer 153 88.24 High High
Apoptosis 37 80.96 Quite High
Disease 154 78.08 Quite High
Disease Progression 3 72.64 Quite High
Skin Cancer 1 68.60 Quite High
Aggression 3 63.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Westin and colleague [14] described that expression of estrogen-induced genes, RALDH2, EIG121, SFRP1, SFRP4, IGF-1, and IGF-IR, tend to be highest in the well-to-moderately differentiated endometrioid carcinoma.
Positive_regulation (induced) of SFRP4 associated with endometroid carcinoma
1) Confidence 0.37 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.98 Pain Relevance 0
It has been suggested that communication and transfer between the peritoneal and uterine cavities occurs in both directions, such that factors secreted in the peritoneal fluid, which baths the reproduction organs, enters the fallopian tubes and reaches the endometrium.
Positive_regulation (reaches) of endometrium in fallopian tubes
2) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.56 Pain Relevance 0.11
As described above, IL-1R1 was down-regulated in the eutopic endometrium of baboons experimentally induced with endometriosis [71].
Positive_regulation (induced) of endometrium in endometrium associated with endometriosis
3) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.74 Pain Relevance 0.32
CYR61 mRNA and protein levels were increased in a time dependent manner in the eutopic endometrium, during the window of receptivity, of baboons experimentally induced with endometriosis [56].
Positive_regulation (increased) of endometrium in endometrium associated with endometriosis
4) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.45 Pain Relevance 0.12

General Comments

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