INT201847

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 5.22
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYR61) extracellular region (CYR61) extracellular matrix organization (CYR61)
Anatomy Link Frequency
endometrium 5
endothelial cells 1
CYR61 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 736 99.92 Very High Very High Very High
chemokine 8 84.72 Quite High
metalloproteinase 96 78.32 Quite High
cytokine 40 70.92 Quite High
Inflammation 56 5.00 Very Low Very Low Very Low
pain pelvic 16 5.00 Very Low Very Low Very Low
Etanercept 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 1048 99.92 Very High Very High Very High
Reprotox - General 1 8 99.92 Very High Very High Very High
Disease 392 98.88 Very High Very High Very High
Reprotox - General 3 104 75.60 Quite High
Apoptosis 56 69.84 Quite High
Congenital Anomalies 16 53.76 Quite High
Repression 16 30.36 Quite Low
INFLAMMATION 64 5.00 Very Low Very Low Very Low
Necrosis 16 5.00 Very Low Very Low Very Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased levels of CYR61 correlate with increased levels of VEGF in both the ectopic and eutopic endometrium of baboons with experimental endometriosis.
Positive_regulation (increased) of CYR61 in endometrium associated with endometriosis
1) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.65 Pain Relevance 0.10
CYR61 mRNA and protein levels were increased in a time dependent manner in the eutopic endometrium, during the window of receptivity, of baboons experimentally induced with endometriosis [56].
Positive_regulation (increased) of CYR61 in endometrium associated with endometriosis
2) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.44 Pain Relevance 0.12
Increased levels of angiogenic factors such as CYR61 and VEGF in ectopic endometriotic lesions presumably promote an increase in the peritoneal vascular network, thereby facilitating implantation and viability of the refluxed endometrium.
Positive_regulation (Increased) of CYR61 in endometrium associated with endometriosis
3) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.60 Pain Relevance 0.08
Increased levels of angiogenic factors such as CYR61 and VEGF in ectopic endometriotic lesions presumably promote an increase in the peritoneal vascular network, thereby facilitating implantation and viability of the refluxed endometrium.
Positive_regulation (Increased) of CYR61 in endometrium associated with endometriosis
4) Confidence 0.36 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.60 Pain Relevance 0.08
Immunohistochemical analysis of the ectopic lesions showed a similar distribution of CYR61 protein to that in eutopic endometrium, with immunostaining primarily in the glandular epithelial and vascular endothelial cells.
Positive_regulation (distribution) of CYR61 in endothelial cells
5) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.60 Pain Relevance 0.07
Increased levels of CYR61, VEGF, and eotaxin in eutopic endometriotic endometrium may increase the angiogenic potential of the tissue and further potentiate the development of lesions.
Positive_regulation (Increased) of CYR61 in endometrium associated with endometriosis
6) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.94 Pain Relevance 0.29
In eutopic endometria of diseased animals, maximal up-regulation of CYR61 was observed at three months following inoculation, with a mean 6.3-fold increase in mRNA levels compared to cycle matched control endometria.
Positive_regulation (regulation) of CYR61
7) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.45 Pain Relevance 0.11
VEGF, CYR61 and c-fos show transient increases during the early stages of disease, while changes in other genes, including ESR1, Pgr-A, and HOXA10, develop at later stages of disease (Figure 4).
Positive_regulation (increases) of CYR61 associated with disease
8) Confidence 0.15 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.94 Pain Relevance 0.24

General Comments

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