INT201853

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.63
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP7) extracellular space (MMP7) extracellular region (MMP7)
proteinaceous extracellular matrix (MMP7)
Anatomy Link Frequency
monocytes 1
cartilage 1
endometrium 1
MMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 29 100.00 Very High Very High Very High
endometriosis 94 97.92 Very High Very High Very High
Osteoarthritis 7 94.76 High High
Inflammation 35 87.80 High High
COX2 2 66.40 Quite High
rheumatoid arthritis 1 62.96 Quite High
Pain 2 12.64 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 131 97.92 Very High Very High Very High
Arthropathy 2 95.88 Very High Very High Very High
Disease 55 95.40 Very High Very High Very High
Osteoarthritis 7 94.76 High High
INFLAMMATION 35 87.80 High High
Injury 2 87.12 High High
Ulcers 2 64.68 Quite High
Rheumatoid Arthritis 1 62.96 Quite High
Peptic Ulcer 2 59.88 Quite High
Cancer 4 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative RT-PCR was performed to examine MMP7 mRNA relative expression.
Spec (examine) Transcription (expression) of MMP7
1) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
To compare MMP7 mRNA relative expression levels between periods, we analyzed the ratio of each independent experiment between the expression level of either MMP7 and GAPDH from the same tissue.
Transcription (expression) of MMP7
2) Confidence 0.52 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
Although eEPCs were grouped with monocytes, some subtle mRNA transcription differences were identified such as complement components (C1QC, C1QB), matrix metalloproteinases (MMP9, MMP7, ADAMDEC1) and osteopontin (SPP1) which were higher in eEPCs than in monocytes.
Transcription (transcription) of MMP7 in monocytes associated with metalloproteinase
3) Confidence 0.21 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0.05
These data were independently validated by Bruner-Tran et al., [31] who demonstrated increased MMP-3 and -7 protein and mRNA levels in the secretory eutopic endometrium of women with endometriosis.
Transcription (levels) of MMP-3 and -7 protein in endometrium associated with endometriosis
4) Confidence 0.03 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 1.08 Pain Relevance 0.47
is a major determinant of catabolic events in cartilage, which results from the stimulation of matrix metalloproteinases (MMPs) transcription and translation, which in turn digest the cartilage matrix.
Transcription (transcription) of matrix in cartilage associated with metalloproteinase
5) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.55 Pain Relevance 0.26

General Comments

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