INT201857

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.06
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYR61) extracellular region (CYR61) extracellular matrix organization (CYR61)
Anatomy Link Frequency
endometrium 1
CYR61 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 368 99.72 Very High Very High Very High
cytokine 20 95.44 Very High Very High Very High
metalloproteinase 48 34.72 Quite Low
Etanercept 4 13.04 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
pain pelvic 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 524 99.72 Very High Very High Very High
Disease 196 97.44 Very High Very High Very High
Reprotox - General 3 52 5.00 Very Low Very Low Very Low
INFLAMMATION 32 5.00 Very Low Very Low Very Low
Apoptosis 28 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CYR61 mRNA is rapidly induced in an immediate early response manner by a spectrum of stimuli including growth factors, cytokines and estrogens [58-60].
Transcription (Expression) of CYR61 associated with cytokine
1) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.60 Pain Relevance 0.20
CYR61 mRNA and protein levels then decreased in eutopic endometria throughout progression of disease, with a mean 3-fold up-regulation 15 months after induction of disease.
Transcription (levels) of CYR61 associated with disease
2) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.50 Pain Relevance 0.07
The highest levels of CYR61 mRNA was observed in the highly vascularized red lesions, with a mean expression level of 18.46 (0.96 – 41.26 n = 8).
Transcription (levels) of CYR61
3) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.52 Pain Relevance 0.04
CYR61 mRNA and protein levels were increased in a time dependent manner in the eutopic endometrium, during the window of receptivity, of baboons experimentally induced with endometriosis [56].
Transcription (levels) of CYR61 in endometrium associated with endometriosis
4) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.44 Pain Relevance 0.12

General Comments

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