INT201858

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.91
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SFRP4) extracellular space (SFRP4) extracellular region (SFRP4)
nucleus (SFRP4) embryo development (SFRP4) cytoplasm (SFRP4)
Anatomy Link Frequency
endometrium 3
SFRP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 184 98.80 Very High Very High Very High
chemokine 2 84.32 Quite High
metalloproteinase 26 75.64 Quite High
Inflammation 14 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
pain pelvic 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 262 100.00 Very High Very High Very High
Reprotox - General 1 4 99.52 Very High Very High Very High
Adenocarcinoma 76 99.32 Very High Very High Very High
Endometrial Stromal Sarcoma 78 98.68 Very High Very High Very High
Endometroid Carcinoma 42 96.76 Very High Very High Very High
Sarcoma 46 96.20 Very High Very High Very High
Carcinoma 122 91.08 High High
Repression 4 89.28 High High
Endometrial Cancer 306 88.24 High High
Cancer 269 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirteen of the analyzed loci showed statistically significant differences in DNA methylation when AD samples were compared to all NTL samples: OPCML, CDX2, HOXA1, CDKN2A EX2, SFRP1, CDH13, TWIST1, LZTS1, RASSF1, SFRP4 and 5, ESR1, and CDH1.
Gene_expression (samples) of SFRP4 associated with adenocarcinoma
1) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 1.25 Pain Relevance 0
Westin and colleague [14] described that expression of estrogen-induced genes, RALDH2, EIG121, SFRP1, SFRP4, IGF-1, and IGF-IR, tend to be highest in the well-to-moderately differentiated endometrioid carcinoma.
Gene_expression (expression) of SFRP4 associated with endometroid carcinoma
2) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0
Compared with normal endometrium, the expression of SFRP4 was decreased in both low grade endometrial stromal sarcomas and undifferentiated endometrial sarcomas.
Gene_expression (expression) of SFRP4 in endometrium associated with sarcoma and endometrial stromal sarcoma
3) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.97 Pain Relevance 0
We have examined the expression of HOXA10 in eutopic endometrium of baboons with experimental endometriosis.
Spec (examined) Gene_expression (expression) of endometrium in endometrium associated with endometriosis
4) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.74 Pain Relevance 0.21
Increased levels of CYR61, VEGF, and eotaxin in eutopic endometriotic endometrium may increase the angiogenic potential of the tissue and further potentiate the development of lesions.
Gene_expression (levels) of endometrium in endometrium associated with endometriosis
5) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.96 Pain Relevance 0.30

General Comments

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