INT201859

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.43
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
Anatomy Link Frequency
fibroblasts 2
pancreatic duct 2
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 184 99.90 Very High Very High Very High
Inflammation 20 95.12 Very High Very High Very High
metalloproteinase 24 91.28 High High
Chronic pancreatitis 9 90.08 High High
imagery 6 9.88 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 262 99.90 Very High Very High Very High
Myelodysplastic Syndromes 58 99.84 Very High Very High Very High
Targeted Disruption 2 99.66 Very High Very High Very High
Myeloid Leukemia 46 99.52 Very High Very High Very High
Cancer 185 99.38 Very High Very High Very High
Repression 5 98.08 Very High Very High Very High
Colon Cancer 2 97.48 Very High Very High Very High
Disease 112 95.76 Very High Very High Very High
INFLAMMATION 22 95.12 Very High Very High Very High
Adenocarcinoma 94 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies using microdissection and immunohistochemistry revealed accumulation of DNA hypermethylation of tumor-related genes associated with DNMT1 overexpression, even in peripheral pancreatic duct epithelia at the precancerous stage [9, 10].
Positive_regulation (overexpression) of Gene_expression (overexpression) of DNMT1 in pancreatic duct associated with cancer
1) Confidence 0.60 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010700 Disease Relevance 0.68 Pain Relevance 0.09
The average number of methylated tumor-related genes and the incidence of DNMT1 overexpression increase progressively with the progression of another precancerous lesion, pancreatic intraductal neoplasia [12], to well-differentiated ductal adenocarcinoma, and finally to poorly differentiated ductal adenocarcinoma, suggesting that DNA methylation alterations participate in multistage pancreatic carcinogenesis [9, 10].
Positive_regulation (overexpression) of Gene_expression (overexpression) of DNMT1 associated with adenocarcinoma and cancer
2) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010700 Disease Relevance 1.23 Pain Relevance 0.09
The average number of methylated tumor-related genes and the incidence of DNMT1 overexpression increase progressively with the progression of another precancerous lesion, pancreatic intraductal neoplasia [12], to well-differentiated ductal adenocarcinoma, and finally to poorly differentiated ductal adenocarcinoma, suggesting that DNA methylation alterations participate in multistage pancreatic carcinogenesis [9, 10].
Positive_regulation (increase) of Gene_expression (overexpression) of DNMT1 associated with adenocarcinoma and cancer
3) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010700 Disease Relevance 1.24 Pain Relevance 0.09
Accordingly, it has been shown that DNMT1 and DNMT3A are overexpressed in MDS and AML samples, when compared to controls [42].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of DNMT1 associated with myeloid leukemia and myelodysplastic syndromes
4) Confidence 0.33 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.13 Pain Relevance 0
OPCML-v1 could also be induced in the colorectal cancer cell line HCT116 which is completely methylated for this gene, by genetic demethylation through double knock-out of both DNA methyltransferases DNMT1 and DNMT3B (DKO cell line) [25] (Fig. 4B).
Positive_regulation (methyltransferases) of Gene_expression (methyltransferases) of DNMT1 associated with targeted disruption and colon cancer
5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
C-fos transformation of rat fibroblasts induces the expression of DNA 5-methylcytosine transferase (dnmt1), which causes hypermethylation and subsequent repression of gene expression by promoting the condensation of chromatin [134-136].
Positive_regulation (induces) of Gene_expression (expression) of dnmt1 in fibroblasts associated with repression
6) Confidence 0.22 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.78 Pain Relevance 0.18
We propose that up-regulation and activity of c-fos seen in the baboon model of endometriosis may induce the expression of dnmt1 and subsequent hypermethylation and down-regulation of endometrial HOXA10 and other progesterone-regulated genes.


Spec (may) Positive_regulation (induce) of Gene_expression (expression) of dnmt1 associated with endometriosis
7) Confidence 0.15 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.72 Pain Relevance 0.30

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