INT201927

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCR) signal transduction (BCR) plasma membrane (BCR)
kinase activity (BCR)
BCR (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 3 40.64 Quite Low
Pain 5 27.80 Quite Low
rheumatoid arthritis 1 16.92 Low Low
corticosteroid 3 16.80 Low Low
cva 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
visual analogue scale 2 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 32 99.80 Very High Very High Very High
Myeloid Leukemia 20 95.64 Very High Very High Very High
Lymphatic System Cancer 10 94.84 High High
Systemic Lupus Erythematosus 7 86.52 High High
Autoimmune Disease 8 80.60 Quite High
Chronic Myelomonocytic Leukemia 15 77.20 Quite High
Myelofibrosis 28 76.96 Quite High
Serum Sickness 4 65.20 Quite High
Disease 28 62.92 Quite High
Disease Progression 5 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By definition, the other MPDs lack the BCR-ABL as a therapeutic target.
Regulation (target) of BCR associated with myeloproliferative disorder
1) Confidence 0.26 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.36 Pain Relevance 0
However, it might also function by signalling through the inhibitory CD22 molecule, causing down-modulation of BCR signalling, as suggested in recent laboratory studies comparing epratuzumab with rituximab [21].
Regulation (modulation) of BCR
2) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779377 Disease Relevance 0.58 Pain Relevance 0

General Comments

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