INT201940

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.46
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8, CXCL10) extracellular space (IL8, CXCL10) extracellular region (IL8, CXCL10)
intracellular (IL8) cell-cell signaling (CXCL10)
Anatomy Link Frequency
monocytes 2
neutrophils 2
Synovial fluids 1
IL8 (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 88 99.50 Very High Very High Very High
spinal inflammation 38 99.26 Very High Very High Very High
rheumatoid arthritis 44 99.18 Very High Very High Very High
chemokine 130 98.74 Very High Very High Very High
Inflammation 156 87.04 High High
cytokine 116 75.80 Quite High
Inflammatory response 8 22.32 Low Low
Inflammatory mediators 28 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Etanercept 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 120 99.56 Very High Very High Very High
Arthritis 54 99.50 Very High Very High Very High
Seronegative Spondarthritis 34 99.36 Very High Very High Very High
Low Back Pain 38 99.26 Very High Very High Very High
Rheumatoid Arthritis 44 99.18 Very High Very High Very High
Rheumatic Diseases 4 98.92 Very High Very High Very High
INFLAMMATION 190 87.04 High High
Apoptosis 12 79.72 Quite High
Infectious Arthritis 2 50.96 Quite High
Peritonitis 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synovial fluids from patients (n = 126) with rheumatic diseases including RA, AS, PsA and CA were analysed for their CXCL8 and CXCL10 content by specific ELISAs (Figure 11).
CXCL8 Spec (analysed) Binding (content) of CXCL10 in Synovial fluids associated with spinal inflammation, rheumatoid arthritis, rheumatic diseases and arthritis
1) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.08 Pain Relevance 0.61
These findings are particularly interesting in view of the angiogenic and antiangiogenic activities of CXCL8 and CXCL10, respectively.
CXCL8 Binding (activities) of CXCL10
2) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.13
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
IL-8 Binding (target) of CXCL10 in monocytes associated with chemokine and infection
3) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.34 Pain Relevance 0.28
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
IL-8 Binding (target) of IP-10 in monocytes associated with chemokine and infection
4) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.34 Pain Relevance 0.28
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
IL-8 Binding (target) of CXCL10 in neutrophils associated with chemokine and infection
5) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.34 Pain Relevance 0.28
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
IL-8 Binding (target) of IP-10 in neutrophils associated with chemokine and infection
6) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.34 Pain Relevance 0.28

General Comments

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