INT201945

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR1, CXCR2) signal transducer activity (CXCR1, CXCR2) signal transduction (CXCR2)
intracellular (CXCR2)
Anatomy Link Frequency
granulocytes 1
leukocyte 1
CXCR1 (Homo sapiens)
CXCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 99.40 Very High Very High Very High
Arthritis 47 93.16 High High
cytokine 57 90.28 High High
rheumatoid arthritis 28 85.56 High High
antagonist 16 81.44 Quite High
Multiple sclerosis 2 71.48 Quite High
MU agonist 8 51.40 Quite High
Inflammation 24 50.00 Quite Low
opioid receptor 19 50.00 Quite Low
agonist 19 35.76 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 30 93.16 High High
Rheumatoid Arthritis 28 85.56 High High
Demyelinating Disease 2 71.48 Quite High
Systemic Lupus Erythematosus 35 69.44 Quite High
Cancer 4 66.00 Quite High
Necrosis 4 65.44 Quite High
INFLAMMATION 27 50.00 Quite Low
Syndrome 5 50.00 Quite Low
Low Back Pain 19 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the CXCR1 receptor was originally reported not to homodimerize or to heterodimerize with the CXCR2 receptor [24], Wilson et al. [21] recently employed a wide range of biochemical and biophysical approaches to demonstrate the capacity of both CXCR1 and CXCR2 to homodimerize and to show that these two GPCRs were able to form heterodimers as effectively as homodimers.
CXCR1 Binding (heterodimerize) of CXCR2 receptor
1) Confidence 0.14 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.08
For example, CXCL8 (IL-8) recognises CXCR1 and CXCR2 and selectively chemoattracts neutrophilic granulocytes, whereas CXCR3 ligands (e.g.
CXCR1 Binding (recognises) of CXCR2 in granulocytes
2) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.20
IL-8/CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte chemotaxis such as polymorphonuclear neutrophils and specific T cells [41, 42].
CXCR1 Binding (ligand) of CXCR2 in leukocyte associated with chemokine
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.62 Pain Relevance 0.52

General Comments

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