INT201950

Context Info Confidence 0.12 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 2.17 Pain Relevance 1.47

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4) Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)

Anatomy Link Frequency fibroblasts 4 IFNA1 (Homo sapiens) DPP4 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 58 96.08 Arthritis 88 83.92 cytokine 52 75.00 Inflammation 28 75.00 spinal inflammation 38 74.72 rheumatoid arthritis 44 70.88 Inflammatory mediators 4 5.00 antagonist 4 5.00 psoriasis 2 5.00 Osteoarthritis 2 5.00

Disease Link Frequency Relevance Heat Arthritis 54 83.92 INFLAMMATION 30 75.00 Low Back Pain 38 74.72 Seronegative Spondarthritis 34 72.80 Rheumatoid Arthritis 44 70.88 Necrosis 6 69.08 Cancer 6 68.72 Arthropathy 6 57.00 Starvation 4 5.00 Rheumatic Diseases 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Together with the expression of CXCL10, the expression of membrane-bound CD26/dipeptidyl peptidase IV was also upregulated in fibroblasts by IFN-?

IFN Positive_regulation (upregulated) of peptidase IV Binding (bound) of in fibroblasts

1) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1779382 Disease Relevance 1.08 Pain Relevance 0.73

Together with the expression of CXCL10, the expression of membrane-bound CD26/dipeptidyl peptidase IV was also upregulated in fibroblasts by IFN-?

IFN Positive_regulation (upregulated) of CD26 Binding (bound) of in fibroblasts

2) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1779382 Disease Relevance 1.08 Pain Relevance 0.73

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