INT201959

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.24
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
Anatomy Link Frequency
fibroblasts 8
T lymphocyte 4
fat 2
nasal 2
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 181 100.00 Very High Very High Very High
cytokine 191 99.90 Very High Very High Very High
Inflammation 163 99.70 Very High Very High Very High
substance P 6 99.44 Very High Very High Very High
Calcitonin gene-related peptide 3 92.52 High High
calcitonin gene related peptide 1 92.28 High High
Neuropeptide 10 86.36 High High
agonist 25 85.84 High High
rheumatoid arthritis 137 84.64 Quite High
spinal inflammation 115 84.32 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 99.90 Very High Very High Very High
INFLAMMATION 168 99.70 Very High Very High Very High
Renal Cancer 78 99.52 Very High Very High Very High
Diabetes Mellitus 120 98.92 Very High Very High Very High
Neurogenic Inflammation 2 98.28 Very High Very High Very High
Chronic Fatigue Syndrome 150 96.28 Very High Very High Very High
Carcinoma 6 96.24 Very High Very High Very High
Myocardial Infarction 4 94.44 High High
Epstein-barr Virus 8 94.12 High High
Cancer 147 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An animal study in rodents even showed that DPP-4 expression in the intestine and kidneys increased with high-fat feeding and type 2 diabetes [18].
Positive_regulation (increased) of Gene_expression (expression) of DPP-4 in fat associated with diabetes mellitus
1) Confidence 0.53 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.68 Pain Relevance 0.08
FACS analysis confirmed the slightly increased CD26 expression on IFN-?
Positive_regulation (increased) of Gene_expression (expression) of CD26
2) Confidence 0.52 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.70 Pain Relevance 0.41
Quantitative DPP IV and NEP expression profile in renal tumors
Positive_regulation (Quantitative) of Gene_expression (expression) of DPP IV associated with renal cancer
3) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.42 Pain Relevance 0
Statistical analyses of grading for cell surface DPP IV (DPP IV/CD26) and staging for both soluble and membrane-bound DPP IV activities were not significant.
Positive_regulation (staging) of Gene_expression (activities) of DPP IV
4) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.37 Pain Relevance 0
It could be demonstrated that DPP-4 inhibition increases circulating levels of GLP-1 in experimental animals and that the insulinotropic action of exogenously administered GLP-1 is intensified by DPP-4 inhibition (Holst and Deacon 1998).
Positive_regulation (increases) of Neg (inhibition) Gene_expression (inhibition) of DPP-4
5) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.20 Pain Relevance 0
Substance P - induced vasodilation was augmented by DPP IV inhibition in an in vivo porcine nasal model [6,8].
Positive_regulation (augmented) of Neg (inhibition) Gene_expression (inhibition) of DPP IV in nasal associated with increased venous pressure under development and substance p
6) Confidence 0.47 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.55 Pain Relevance 0.51
FACS analysis confirmed the slightly increased CD26 expression on IFN-?
Positive_regulation (increased) of Gene_expression (expression) of CD26
7) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.70 Pain Relevance 0.41
Tissue cells, however, including fibroblasts, also express chemokine degrading enzymes such as DPP IV/CD26, the expression of which is upregulated on fibroblasts in response to IFN-?.
Positive_regulation (upregulated) of Gene_expression (expression) of CD26 in fibroblasts associated with chemokine
8) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.45 Pain Relevance 0.53
Tissue cells, however, including fibroblasts, also express chemokine degrading enzymes such as DPP IV/CD26, the expression of which is upregulated on fibroblasts in response to IFN-?.
Positive_regulation (upregulated) of Gene_expression (expression) of DPP IV in fibroblasts associated with chemokine
9) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.45 Pain Relevance 0.53
To investigate whether DPP IV activity (or CD26 expression) could be upregulated in fibroblasts by cytokines under similar conditions to those used to induce CXCL10, cell cultures were stimulated with IL-1?
Positive_regulation (upregulated) of Gene_expression (expression) of CD26 in fibroblasts associated with cytokine
10) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.05
have been reported to stimulate the expression of other chemokine processing proteases such as CD26/dipeptidyl peptidaseIV (DPP IV) (EC 3.4.14.5) in fibroblasts, whereas for TNF-?
Positive_regulation (stimulate) of Gene_expression (expression) of CD26 in fibroblasts associated with chemokine
11) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.31 Pain Relevance 0.37
T lymphocytes from labouring women showed significantly higher expression of CD26 (P < 0.001) and CD62L (P < 0.01) compared with non-labouring women.
Positive_regulation (showed) of Gene_expression (expression) of CD26 in T lymphocytes
12) Confidence 0.12 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.07 Pain Relevance 0
Immune activation is also suggested by an elevation of pro-inflammatory cytokines, an increased expression of T lymphocyte activation markers, such as CD26 and CD38 [12] and decreased function of natural killer (NK) cells (for review see [13]).
Positive_regulation (increased) of Gene_expression (expression) of CD26 in T lymphocyte associated with inflammation and cytokine
13) Confidence 0.06 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 1.22 Pain Relevance 0.50

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