INT20196

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Context Info
Confidence 0.07
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.49
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
blood 2
KTP 2
Platelet 2
PGE2 2
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 100.00 Very High Very High Very High
cINOD 21 99.98 Very High Very High Very High
Paracetamol 3 99.92 Very High Very High Very High
acular 19 99.54 Very High Very High Very High
narcan 3 96.32 Very High Very High Very High
antagonist 2 95.04 Very High Very High Very High
anesthesia 17 93.84 High High
agonist 5 93.48 High High
Opioid 2 92.60 High High
analgesia 2 92.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 96.32 Very High Very High Very High
Coagulation Disorder 2 95.12 Very High Very High Very High
Hemorrhage 11 93.88 High High
Toxicity 2 86.64 High High
Crystal Associated Disease 1 84.88 Quite High
Peritonitis 1 82.24 Quite High
Ulcers 2 79.80 Quite High
Arthritis 2 75.76 Quite High
Pain 3 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KT despite near complete abolition of TxB2 production.
Negative_regulation (abolition) of Gene_expression (production) of TxB2 associated with acular
1) Confidence 0.07 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7598238 Disease Relevance 0.06 Pain Relevance 0.96
Both NSAIDs inhibited the production of TxB2 to a similar extent.
Negative_regulation (inhibited) of Gene_expression (production) of TxB2 associated with cinod
2) Confidence 0.02 Published 1995 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7674450 Disease Relevance 0.33 Pain Relevance 1.20
mice (269.55 ± 77.48 ng/mg CRE vs 929.17 ± 196.29 ng/mg CRE, p = 0.012), and inhibited the production of urinary TxB2 by 26.2% compared to pre medication in men (0.53 ± 0.10 ng/mg CRE vs 2.04 ± 0.12 ng/mg CRE, p = 0.001) (Fig. 1A and D).
Negative_regulation (inhibited) of Gene_expression (production) of TxB2
3) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935154 Disease Relevance 0.06 Pain Relevance 0
SK&F 105809 inhibited LTB4 and PGE2 production in vivo in inflammatory exudates as well as the production of LTB4 and thromboxane B2 (TxB2) ex vivo in rat blood.
Negative_regulation (inhibited) of Gene_expression (production) of TxB2 in blood associated with inflammation
4) Confidence 0.00 Published 1990 Journal Drugs Exp Clin Res Section Abstract Doc Link 2127565 Disease Relevance 0.85 Pain Relevance 0.31
Platelet TxB2 production decreased dramatically in the ketorolac group from preoperative to poststudy drug data points (157.2 +/- 129.4 to 0.3 +/- 0.3 ng/mL; P < 0.01).
Negative_regulation (decreased) of Gene_expression (production) of TxB2 in Platelet associated with acular
5) Confidence 0.00 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8638787 Disease Relevance 0.15 Pain Relevance 1.26
Meloxicam significantly decreased TxB2 production compared with placebo in a dose-dependent fashion, reaching a peak of 77% inhibition 6 hours after 30 mg meloxicam; Indo-ER blocked TxB2 formation by 96% at the same time point.
Negative_regulation (decreased) of Gene_expression (production) of TxB2
6) Confidence 0.00 Published 2002 Journal J Clin Pharmacol Section Abstract Doc Link 12162470 Disease Relevance 0.68 Pain Relevance 0.43
Phenacetin was even less potent than paracetamol to reduce the production of both TxB2 and PGE2, and no clear preference for either of the COX-enzymes was seen.
Negative_regulation (reduce) of Gene_expression (production) of TxB2 in PGE2 associated with paracetamol
7) Confidence 0.00 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592552 Disease Relevance 0.17 Pain Relevance 0.35
Both rac-KTP and the separate enantiomers produced marked inhibition of serum thromboxane B2 (TxB2) synthesis (ex vivo) and moderate inhibition of exudate prostaglandin E2 (PGE2) synthesis (in vivo); pharmacodynamic variables for S(+) KTP were Emax (%) = 94 and 100; IC50 (microg/mL) = 0.0033 and 0.0030; N = 0.45 and 0.58, respectively, where Emax is the maximal effect, IC50 the plasma drug concentration producing 50% of Emax and N the slope of log concentration/effect relationship.
Negative_regulation (inhibition) of Gene_expression (synthesis) of TxB2 in KTP
8) Confidence 0.00 Published 2003 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 12667184 Disease Relevance 0.19 Pain Relevance 0.13

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