INT201961

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.66
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
photoreceptor 1
inner plexiform layer 1
ap (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 885 100.00 Very High Very High Very High
cva 2 77.48 Quite High
ketamine 4 68.48 Quite High
Inflammation 9 65.20 Quite High
anesthesia 4 31.96 Quite Low
cytokine 4 17.08 Low Low
unmyelinated 40 5.00 Very Low Very Low Very Low
Pyramidal cell 30 5.00 Very Low Very Low Very Low
Axonal channel 20 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 92.40 High High
Retina Disease 4 78.88 Quite High
Respiratory Syncytial Virus 26 78.80 Quite High
Cataract 2 76.16 Quite High
Ocular Toxicity (including Many Sub-types) 6 75.76 Quite High
INFLAMMATION 9 65.20 Quite High
Cytomegalovirus Infection 46 59.36 Quite High
Blister 2 56.20 Quite High
Necrosis 2 19.20 Low Low
Cancer 6 18.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AP expression was observed in the RPE, outer nuclear layer (ONL), inner nuclear layer (INL), OPL, inner plexiform layer (IPL), RGC layer and Müller cells but not the outer and inner segments of the photoreceptor (Figure 1C,E-H).
Positive_regulation (observed) of in inner plexiform layer Gene_expression (expression) of AP in photoreceptor
1) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.23 Pain Relevance 0
After endogenous heat labile AP activity was heat inactivated, AAV-9 mediated AP expression was examined by histochemical staining using a previously described protocol [22-24].
Positive_regulation (mediated) of Spec (examined) Gene_expression (expression) of AP
2) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.36 Pain Relevance 0.07
Yet, in marked contrast to AP initiation, during AP propagation the ionic (Na and K) currents trail the early rising phase of the AP (in Figure 3C between ?
Positive_regulation (during) of Gene_expression (initiation) of AP associated with action potential
3) Confidence 0.22 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.48
Having described the four stochastic effects that occur during AP conduction, we consider how these effects are caused by channel noise at a mechanistic level.
Positive_regulation (occur) of Gene_expression (conduction) of AP associated with action potential
4) Confidence 0.19 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.23
Yet, in marked contrast to AP initiation, during AP propagation the ionic (Na and K) currents trail the early rising phase of the AP (in Figure 3C between ?
Positive_regulation (during) of Gene_expression (propagation) of AP associated with action potential
5) Confidence 0.19 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.46
Splitting is caused by gradual conduction fluctuations and jump-like events acting together in a structured manner, such as to systematically accelerate or decelerate APs within an AP set as it propagates along the axon.
Positive_regulation (decelerate) of Gene_expression (decelerate) of AP associated with action potential
6) Confidence 0.19 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
Therefore, the rising AP phase extends as far ahead as the forward axial current (in Figure 3C at ?
Positive_regulation (rising) of Gene_expression (phase) of AP associated with action potential
7) Confidence 0.19 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.44
No activation of AP expression took place distant from those sites.
Neg (No) Positive_regulation (activation) of Gene_expression (expression) of AP
8) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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