INT201962

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
bursa 1
bone marrow 1
PC-3 1
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 68.32 Quite High
rheumatoid arthritis 35 59.76 Quite High
Osteoarthritis 33 59.20 Quite High
antagonist 20 50.00 Quite Low
chemokine 2 46.48 Quite Low
cytokine 21 46.00 Quite Low
fibrosis 5 17.44 Low Low
Arthritis 17 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 3 98.88 Very High Very High Very High
Breast Cancer 3 98.72 Very High Very High Very High
Metastasis 60 98.60 Very High Very High Very High
Prostate Cancer 6 98.60 Very High Very High Very High
Reprotox - General 1 26 98.36 Very High Very High Very High
Cancer 157 98.16 Very High Very High Very High
Malignant Neoplastic Disease 8 97.48 Very High Very High Very High
Obesity 8 96.80 Very High Very High Very High
Recurrence 1 94.28 High High
Melanoma 5 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Transcription (concentrations) of rhBMP-2
1) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
On the other hand, the mRNA level of BMP-2 was significantly decreased in breast cancer tumors compared to normal breast tissue [47].

2.2.3.

Transcription (level) of BMP-2 associated with cancer and breast cancer
2) Confidence 0.27 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.09 Pain Relevance 0
Guo et al (1999) reported expression of BMP-2 receptor mRNA was correlated with metastasis of osteosarcoma.
Transcription (expression) of BMP-2 associated with osteogenic sarcomas and metastasis
3) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 1.04 Pain Relevance 0
3, induced chondrogenic phenotype in cultured human bone marrow-derived MSC pellets, with BMP-2 seemingly the most effective [20].
Transcription (derived) of BMP-2 in bone marrow
4) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.22 Pain Relevance 0.06
The mRNA expression of BMP-2,-3,-6 and -7 was not modified in both Nog-KD clones as compared to parental PC-3, while BMP-4 mRNA was undetectable in both parental and Nog-KD cells (not shown).
Transcription (expression) of BMP-2 in PC-3
5) Confidence 0.07 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 0.10 Pain Relevance 0
Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue.
Transcription (found) of BMP-2 in bursa
6) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1779385 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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