INT201967

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.24
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
bone marrow 1
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 98.56 Very High Very High Very High
Inflammation 11 84.80 Quite High
cytokine 10 67.60 Quite High
antagonist 1 40.56 Quite Low
fibrosis 5 9.40 Low Low
Pain 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 13 99.00 Very High Very High Very High
Osteoarthritis 97 98.56 Very High Very High Very High
Closed Fractures 2 97.04 Very High Very High Very High
Fracture Healing 32 85.76 High High
INFLAMMATION 11 84.80 Quite High
Death 1 80.84 Quite High
Soft Tissue Injuries 1 75.24 Quite High
Disease 15 72.00 Quite High
Rupture 4 56.88 Quite High
Hypertrophy 7 44.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of SB431542 in a BMP-2 induced bone formation model
Positive_regulation (induced) of BMP-2
1) Confidence 0.31 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.08 Pain Relevance 0
Using a novel adenoviral gene therapy technique, Lieberman et al (1999) used BMP-2 producing bone marrow cells to treat rats with femoral defects.
Positive_regulation (used) of BMP-2 in bone marrow
2) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.33 Pain Relevance 0
type II receptor has also been observed by our own group during ageing and OA in murine models [52,53].
Positive_regulation (observed) of type II receptor associated with aging and osteoarthritis
3) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.49 Pain Relevance 0.19
With the present set of data, an additional perspective towards a causative explanation is given: chronic activation of morphogenetic factors (BMP-2, BMP-7, TGF-?
Positive_regulation (activation) of BMP-2
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.35 Pain Relevance 0.14

General Comments

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