INT20200

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 17.08
Pain Relevance 4.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1) extracellular region (Serpinc1)
Anatomy Link Frequency
platelets 5
skin 2
liver 1
foramen ovale 1
Serpinc1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 100.00 Very High Very High Very High
Pain 18 99.80 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 13 99.32 Very High Very High Very High
Paracetamol 6 99.20 Very High Very High Very High
Crohn's disease 4 95.60 Very High Very High Very High
Angina 25 95.48 Very High Very High Very High
Inflammation 9 94.76 High High
headache 2 93.88 High High
cva 155 92.32 High High
cINOD 1 91.52 High High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 19 100.00 Very High Very High Very High
Acute Coronary Syndrome 10 99.98 Very High Very High Very High
Congenital Anomalies 5 99.92 Very High Very High Very High
Disease 37 99.86 Very High Very High Very High
Pain 14 99.80 Very High Very High Very High
Overdose 3 99.56 Very High Very High Very High
Disease Progression 2 99.42 Very High Very High Very High
Herpes Zoster 12 99.16 Very High Very High Very High
Injury 20 98.92 Very High Very High Very High
Thrombophilia 10 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It lowers apoprotein A1 and increases antithrombin 3, but these changes produce no adverse effects.
Positive_regulation (increases) of antithrombin 3
1) Confidence 0.68 Published 1993 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12318010 Disease Relevance 0.41 Pain Relevance 0.08
Heparin achieves its prophylactic benefit by activating antithrombin III.
Positive_regulation (activating) of antithrombin
2) Confidence 0.59 Published 1985 Journal Am. J. Surg. Section Abstract Doc Link 3901791 Disease Relevance 0.47 Pain Relevance 0.08
It has been shown that 1 micrograms of antithrombin III inhibits the formation of 1 unit of thrombin; however, in the presence of heparin, 1 micrograms of activated antithrombin III inhibits 750 units of thrombin.
Positive_regulation (activated) of antithrombin
3) Confidence 0.59 Published 1985 Journal Am. J. Surg. Section Abstract Doc Link 3901791 Disease Relevance 0.48 Pain Relevance 0.07
Activated antithrombin III affects numerous sites in the coagulation cascade.
Positive_regulation (Activated) of antithrombin
4) Confidence 0.59 Published 1985 Journal Am. J. Surg. Section Abstract Doc Link 3901791 Disease Relevance 0.46 Pain Relevance 0.08
It has been suggested that a hypercoagulable state is associated with clinical activity of the disease, with elevation of factors V, VIII, fibrinogen and platelets and a lowering of anti-thrombin III.
Positive_regulation (elevation) of anti-thrombin III in platelets associated with thrombophilia and disease
5) Confidence 0.39 Published 1998 Journal P R Health Sci J Section Abstract Doc Link 9883477 Disease Relevance 1.08 Pain Relevance 0.27
Elevation of factor VIII, platelets, and antithrombin III were found.
Positive_regulation (Elevation) of antithrombin III in platelets
6) Confidence 0.39 Published 1998 Journal P R Health Sci J Section Abstract Doc Link 9883477 Disease Relevance 1.04 Pain Relevance 0.26
Potential advantages of bivalirudin include a lack of dependence on antithrombin III for anticoagulant activity, the ability to inactivate both fibrin-bound and soluble thrombin, a lack of aggregatory effects on platelets, a predictable anticoagulant response without monitoring, and a wider therapeutic window.
Positive_regulation (dependence) of antithrombin in platelets associated with addiction
7) Confidence 0.26 Published 2001 Journal Curr Cardiol Rep Section Abstract Doc Link 11504570 Disease Relevance 0.36 Pain Relevance 0.24
The mixture of polysulfated glycosaminoglycans called heparin binds to and activates antithrombin.
Positive_regulation (activates) of antithrombin
8) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994024 Disease Relevance 0.10 Pain Relevance 0.05
A detailed examination of the gene profiles was employed using the signal to noise ratio, ANOVA, Student's t-test, and fold changes, and resulted in fifteen genes that are potential biomarkers of disease progression in need of further testing: SERPINC1 (462), DHFRL1 (200895), IRX2 (153572), SGCE (8910), ADAM23 (8745), TBX3 (6926), SLC5A4 (6527), CCAR1 (55749), MS4A2 (2206), IMPACT (55364), NDUFA5 (4698), CEACAM6 (4680), C10orf88 (80007), ITGA4 (3676), and CD69 (969) (first seven genes are upregulated and the subsequent eight genes are downregulated).
Positive_regulation (upregulated) of SERPINC1 associated with disease progression
9) Confidence 0.19 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.62 Pain Relevance 0
Up-regulation of prothrombin expression by the vascular endothelial and sweat gland epithelial cells in the active skin lesion and transient elevation of plasma thrombin-antithrombin III complex levels in a proportion of patients suggest a lesional generation of thrombin in herpes zoster.
Positive_regulation (regulation) of thrombin-antithrombin in skin associated with herpes zoster
10) Confidence 0.18 Published 2001 Journal J. Dermatol. Section Abstract Doc Link 11449671 Disease Relevance 0.89 Pain Relevance 0.61
Up-regulation of prothrombin expression by the vascular endothelial and sweat gland epithelial cells in the active skin lesion and transient elevation of plasma thrombin-antithrombin III complex levels in a proportion of patients suggest a lesional generation of thrombin in herpes zoster.
Positive_regulation (elevation) of thrombin-antithrombin in skin associated with herpes zoster
11) Confidence 0.18 Published 2001 Journal J. Dermatol. Section Abstract Doc Link 11449671 Disease Relevance 0.85 Pain Relevance 0.58
RESULTS: After 1 week of treatment, a significant increase of ATIII (p < 0.05), fV (p < 0.01) and vWF (p < 0.05) was found in the control group, but not in atorvastatin-treated group.
Positive_regulation (increase) of ATIII
12) Confidence 0.15 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16337041 Disease Relevance 0.08 Pain Relevance 0
Thrombin-antithrombin and soluble tissue factor levels increased in those with acute liver injury, but were normal in patients with cirrhosis.
Positive_regulation (increased) of antithrombin in liver associated with cirrhosis and injury
13) Confidence 0.13 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 14567536 Disease Relevance 1.57 Pain Relevance 0.26
PCI in ACS requires adjunctive antiplatelet and antithrombin therapy, and, in general, coronary stenting is advisable.
Positive_regulation (requires) of antithrombin associated with acute coronary syndrome
14) Confidence 0.12 Published 2002 Journal Prog Cardiovasc Dis Section Abstract Doc Link 12077719 Disease Relevance 1.35 Pain Relevance 0.26
Thrombin is inhibited in circulation by antithrombin III, and measurement of the thrombin-antithrombin III complex (TAT) is a direct measure of thrombin formation.
Positive_regulation (measurement) of antithrombin III
15) Confidence 0.12 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2127751 Disease Relevance 0.81 Pain Relevance 0
There was also evidence of thrombin generation as indicated by the elevated levels of fibrinopeptide A (FPA) and thrombin-antithrombin complexes.
Positive_regulation (elevated) of thrombin-antithrombin
16) Confidence 0.06 Published 1994 Journal Int. J. Cardiol. Section Abstract Doc Link 8181885 Disease Relevance 0.42 Pain Relevance 0.34
There was also evidence of thrombin generation as indicated by the elevated levels of fibrinopeptide A (FPA) and thrombin-antithrombin complexes.
Positive_regulation (levels) of thrombin-antithrombin
17) Confidence 0.06 Published 1994 Journal Int. J. Cardiol. Section Abstract Doc Link 8181885 Disease Relevance 0.42 Pain Relevance 0.34
Hemoglobin, hematocrit, platelets, fibrinogen, prothrombin time, thrombin time, activated partial thromboplastin time, antithrombin, and protein C were measured immediately on arrival at the laboratory.
Spec (partial) Positive_regulation (activated) of antithrombin in platelets
18) Confidence 0.05 Published 2003 Journal J Clin Anesth Section Body Doc Link 14652120 Disease Relevance 0 Pain Relevance 0
The levels of prothrombin fragment 1+2 and thrombin antithrombin III complex increased markedly during percutaneous transluminal coronary angioplasty.
Positive_regulation (increased) of antithrombin associated with percutaneous transluminal coronary angioplasty
19) Confidence 0.05 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 10822073 Disease Relevance 0.36 Pain Relevance 0.69
UFH consists of an heterogeneous mixture of polysaccharide chains with a molecular weight of 3,000 to 30,000 daltons, and acts as an anticoagulant by activating anti-thrombin.
Positive_regulation (activating) of anti-thrombin
20) Confidence 0.05 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.12 Pain Relevance 0.03

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