INT202043

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0.54

extracellular space (MMP13, COL2A1) extracellular region (MMP13, COL2A1) peptidase activity (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) cytoplasm (COL2A1)

Anatomy Link Frequency cleavage 2 MMP13 (Homo sapiens) COL2A1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 60 100.00 rheumatoid arthritis 16 96.80 Inflammation 18 95.24 Arthritis 39 74.24 Osteoarthritis 18 5.00 cytokine 4 5.00 chemokine 4 5.00 methotrexate 1 5.00 cINOD 1 5.00 Inflammatory marker 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 16 96.80 INFLAMMATION 13 95.24 Arthritis 44 75.28 Disease 8 69.32 Juvenile Chronic Polyarthritis 1 64.40 Disease Progression 1 25.20 Osteoarthritis 19 5.00 Rheumatic Diseases 2 5.00 Ankylosing Spondylitis 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since we found that MMP-2 is mostly found in its proform in SF, our results favour the implication of MMP-13 Interestingly, MMP-13, which is responsible for cleavage of type II collagen [36,37], aggrecan [38], and fibrinogen [39], has been shown to be increased in RA SF [3] and to be linked to synovial inflammation and bone destruction [40].

MMP-13 Regulation (responsible) of Protein_catabolism (cleavage) of type II collagen in cleavage associated with inflammation, rheumatoid arthritis and metalloproteinase

1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.54 Pain Relevance 0.54

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