INT20205

Context Info Confidence 0.46 First Reported 1982 Last Reported 2010 Negated 7 Speculated 3 Reported most in Body Documents 108 Total Number 111 Disease Relevance 66.68 Pain Relevance 8.57

Anatomy Link Frequency capsule 5 brain 3 spinal cord 3 macrophages 2 neural 2 IgG (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 410 99.88 Inflammation 595 99.82 Central nervous system 669 99.68 rheumatoid arthritis 327 99.64 midbrain 25 99.54 Arthritis 353 98.88 imagery 176 94.24 Substantia nigra 127 93.96 cva 48 93.76 local anesthetic 3 92.60

Disease Link Frequency Relevance Heat Neuromyelitis Optica 2628 100.00 Bullous Skin Disease 1826 100.00 Dengue 328 100.00 Togavirus Infection 316 100.00 Motor Neuron Diseases 188 100.00 Lymphatic System Cancer 20 99.92 Rheumatoid Arthritis 344 99.84 INFLAMMATION 672 99.82 Mitral Valve Prolapse 108 99.72 Rickettsiaceae Infection 303 99.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This is supported by the association of IgG against murine typhus with higher building density and closeness to markets and is reflected in the old name of ‘shop typhus’ for murine typhus.

IgG Binding (association) of associated with rickettsiaceae infection and epidemic louse-borne typhus

1) Confidence 0.46 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 1.03 Pain Relevance 0

Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica.

IgG Binding (binding) of associated with neuromyelitis optica

2) Confidence 0.36 Published 2007 Journal Neurology Section Title Doc Link 17928579 Disease Relevance 0.89 Pain Relevance 0.18

The phenomenon is interpreted as partial and transient internalization of IgG molecules in the membrane.

IgG Spec (partial) Binding (internalization) of

3) Confidence 0.36 Published 1982 Journal Immunol. Lett. Section Abstract Doc Link 6299936 Disease Relevance 0 Pain Relevance 0.09

In multivariate analysis (Table 5), four characteristics were significantly associated with IgG antibodies against murine typhus - living in Vientiane for more than one third of their lifetime, being a retail trader, staying at home or not working, living close to markets (<750 m) and in neighborhoods with high building density increased significantly the risk for past infection with murine typhus.

IgG Binding (associated) of associated with rickettsiaceae infection and infection

4) Confidence 0.36 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.95 Pain Relevance 0

In multivariate analysis, eleven characteristics remained significantly associated with IgG antibodies against scrub typhus.

IgG Binding (associated) of associated with rickettsiaceae infection

5) Confidence 0.36 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.81 Pain Relevance 0

Four weeks after the first application of MAb BW 494, 17/18 patients presented with HAMA (IgG).

IgG Binding (presented) of

6) Confidence 0.34 Published 1988 Journal Int. J. Cancer Suppl. Section Abstract Doc Link 3162451 Disease Relevance 0.87 Pain Relevance 0.09

There was also evidence of IgG intake in endothelial cells in affected areas of the spinal cord in both ALS patients and mice injected with human ALS IgG.

IgG Binding (injected) of in endothelial cells associated with motor neuron diseases and spinal cord

7) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.59 Pain Relevance 0.22

As compared to IgG acquired via intravenous injection, it is possible that ingested IgG selected by FcRn for absorption from the gut lumen has a higher binding affinity for FcRn systemically, and thereby has increased protection from catabolism.

IgG Binding (binding) of in lumen

8) Confidence 0.24 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0 Pain Relevance 0

The ability of maternal IgG to mediate differential effects in offspring may be related to affinities for individual Fc?

IgG Binding (mediate) of

9) Confidence 0.24 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.09 Pain Relevance 0.03

These findings may indicate that RA RF is capable of binding IgG as well as another self or foreign antigen.

IgG Binding (binding) of associated with rheumatoid arthritis

10) Confidence 0.24 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 0.68 Pain Relevance 0.26

Figure 1 demonstrates the prevalence of IgG associated with the retinal capillaries in both normal and laser-photocoagulated retinas.

IgG Binding (associated) of in retinas

11) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2794657 Disease Relevance 0 Pain Relevance 0

The reverse association for rubella virus with T. gondii IgG seropositivity is probably related to higher socioeconomic status, which entails better access to health care, more hygienic living conditions, and less occupational contact with soil.

IgG Binding (association) of associated with togavirus infection

12) Confidence 0.22 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2844547 Disease Relevance 1.74 Pain Relevance 0

We recently discovered a unique IgG autoantibody (NMO-IgG) that is highly specific to patients with NMO and thus a valuable diagnostic aid.

IgG Binding (specific) of associated with neuromyelitis optica

13) Confidence 0.20 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.17 Pain Relevance 0.21

The chemotactic effects of C5a-C5aR ligation then attracts neutrophils to sites of inflammation to produce properdin, which, upon binding to C3b-IgG complexes, enhances the association with factor B, leading to stabilization of the alternative pathway C3 convertase and amplification of the alternative pathway C3 consumption.

IgG Binding (binding) of in neutrophils associated with inflammation

14) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.70 Pain Relevance 0.25

Several lines of evidence suggest that this occurs via a mechanism in which IgG first binds to C. neoformans capsule and then SP-A binds to bound IgG.

IgG Binding (binds) of in capsule

15) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2147053 Disease Relevance 0.10 Pain Relevance 0

Several lines of evidence suggest that this occurs via a mechanism in which IgG first binds to C. neoformans capsule and then SP-A binds to bound IgG.

IgG Binding (binds) of in capsule

16) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2147053 Disease Relevance 0.05 Pain Relevance 0

Therefore, we investigated whether IgG antibody binding to capsule enabled SP-A binding to C. neoformans.

IgG Spec (whether) Binding (binding) of in capsule

17) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2147053 Disease Relevance 0 Pain Relevance 0

Acute H. pylori was defined as a positive 13C-urea breath test result and negative IgG serology for H. pylori.

IgG Neg (negative) Binding (serology) of

18) Confidence 0.19 Published 2000 Journal J. Pediatr. Gastroenterol. Nutr. Section Body Doc Link 11045838 Disease Relevance 0.07 Pain Relevance 0

This antibody has not yet been proven to be pathogenic, but several facts suggest that it might be, including the similarity of the immunohistochemical pattern of NMO-(AQP4) IgG binding to mouse CNS tissues to the pattern of immune complex deposition in autopsied patients' spinal cord tissue.

IgG Binding (binding) of in spinal cord associated with neuromyelitis optica and spinal cord

19) Confidence 0.19 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.17 Pain Relevance 0.35

This has been attributed to the ability IgG2a to interact with all three activating IgG Fc receptors, Fc?

IgG Binding (receptors) of

20) Confidence 0.17 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.19 Pain Relevance 0

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