INT202063

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.14
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
liver 2
T-cell 2
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 99.90 Very High Very High Very High
Inflammation 95 99.70 Very High Very High Very High
fibrosis 18 99.20 Very High Very High Very High
rheumatoid arthritis 37 77.20 Quite High
Arthritis 33 56.72 Quite High
Inflammatory response 15 44.76 Quite Low
metalloproteinase 6 42.24 Quite Low
chemokine 11 41.00 Quite Low
agonist 54 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 61 100.00 Very High Very High Very High
INFLAMMATION 113 99.70 Very High Very High Very High
Fibrosis 24 99.20 Very High Very High Very High
Liver Disease 6 90.80 High High
Injury 31 88.88 High High
Alcoholic Liver Diseases 2 88.44 High High
Hepatitis Virus Infection 2 86.68 High High
Disease 16 85.84 High High
Cancer 7 83.60 Quite High
Rheumatoid Arthritis 37 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activation, such as pro-inflammatory cytokines and ligation of Toll-like receptors, but triggering of highly specialized antigen receptors such as the T-cell receptor is also dependent on this pathway [12].
Regulation (dependent) of Toll Binding (ligation) of in T-cell associated with inflammation and cytokine
1) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.89 Pain Relevance 0.35
Recent studies have uncovered an important role for TLR4 signaling in liver fibrogenesis and the association of TLR4 polymorphisms with fibrosis risk.
Regulation (role) of TLR4 Binding (association) of in liver associated with fibrosis and cirrhosis
2) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.25 Pain Relevance 0.13

General Comments

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