INT20207

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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 2.88
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B cells 1
egg 1
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 1 99.68 Very High Very High Very High
rheumatoid arthritis 57 96.16 Very High Very High Very High
Inflammation 157 93.84 High High
Morphine 8 93.40 High High
Kinase C 1 91.08 High High
cytokine 65 90.88 High High
abdominal pain 1 87.92 High High
agonist 3 86.40 High High
analgesia 5 84.92 Quite High
opioid receptor 4 82.36 Quite High
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 56 98.44 Very High Very High Very High
Rheumatoid Arthritis 57 96.16 Very High Very High Very High
Peripheral Arterial Disease 2 94.12 High High
INFLAMMATION 177 93.84 High High
Atherosclerosis 137 93.32 High High
Adhesions 15 93.20 High High
Apoptosis 18 92.40 High High
Systemic Lupus Erythematosus 8 86.60 High High
Rickettsiaceae Infection 86 86.00 High High
Anaphylaxis 2 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggested that, after treatment with PZQ, miracidia within eggs in host tissues hatched and that there was increased release of egg antigen which was bound by IgM to produce CIC.
IgM Binding (bound) of in egg
1) Confidence 0.46 Published 1988 Journal Jpn. J. Exp. Med. Section Abstract Doc Link 3411793 Disease Relevance 0.14 Pain Relevance 0.09
Results were recorded as positive, equivocal, or negative for the IgM against O. tsutsugamushi and control lines.
IgM Binding (negative) of
2) Confidence 0.35 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.42 Pain Relevance 0
This finding was also clearly demonstrated by increased accuracy when ST ICT and MT IBT results for paired samples with admission IgM titers ?
IgM Binding (samples) of
3) Confidence 0.35 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0
The anti-bacterial IgM induced was specific to the commensal microflora of the host and did not bind to Salmonella, which these mice have never been exposed to (Figure S7).
IgM Neg (not) Binding (bind) of
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0 Pain Relevance 0
The exact identities of the commensals to which gluten and indomethacin-treated mice are systemically primed in this model are not yet known but the absence of IgM binding to Salmonella, known to be absent from the commensal flora of our mice, strongly suggests the specificity of the IgM antibodies against commensal flora in our mice (Figure S7).
IgM Binding (binding) of
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.06 Pain Relevance 0.07
These clones were found to be of Ig(G) class and IgM class with kappa and lambda light chain.
IgM Binding (be) of
6) Confidence 0.26 Published 2002 Journal Hybrid. Hybridomics Section Abstract Doc Link 12165146 Disease Relevance 0.07 Pain Relevance 0.31
However, IgM-bearing kappa light chains were recognized by immunocytochemistry.
IgM Binding (recognized) of
7) Confidence 0.12 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0.10
In contrast, in this type of assay, McC10 did not appear to recognize mouse IgA, IgM or lambda light chains.
IgM Binding (recognize) of
8) Confidence 0.12 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0.09
Levels of C4 fragments at these sites also correlated with titers of IgM RFs.
IgM Binding (titers) of
9) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 1.04 Pain Relevance 0.46
Rat anti-mouse IgG from Zymed (San Francisco, CA, USA) was used to detect total Ig; the isotype-specific antibodies used to detect IgG1, IgG2a, and IgM were also purchased from Zymed.
IgM Binding (detect) of
10) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0
IgG2a-chromatin immune complexes require the synergistic engagement of IgM and TLR9 to activate B cells [31].
IgM Binding (engagement) of in B cells
11) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.17 Pain Relevance 0
recognised by the antibodies generated, mainly IgM.
IgM Binding (recognised) of
12) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.31 Pain Relevance 0.09
that IgM antibodies may bind to oxLDL preventing its binding and degradation by
IgM Binding (bind) of
13) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.67 Pain Relevance 0.03
The affinity of HmuOR for an opioid ligand and its ability to mediate the activation of a G-protein were not altered by their interaction.
HmuOR Binding (affinity) of associated with opioid
14) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.56

General Comments

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