INT2021

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.20
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
Blood 1
plasma 1
liver 1
platelet 1
respiratory 1
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Regional anesthesia 7 96.32 Very High Very High Very High
cINOD 7 96.32 Very High Very High Very High
Paracetamol 14 96.04 Very High Very High Very High
Angina 1 92.96 High High
local anesthetic 4 92.08 High High
Catecholamine 5 81.52 Quite High
lidocaine 24 78.48 Quite High
adenocard 2 75.84 Quite High
ischemia 6 74.68 Quite High
fluoxetine 2 71.92 Quite High
Disease Link Frequency Relevance Heat
Respiratory Failure 1 99.40 Very High Very High Very High
Methemoglobinemia 81 98.44 Very High Very High Very High
Poisoning 4 95.48 Very High Very High Very High
Death 12 95.12 Very High Very High Very High
Pressure And Volume Under Development 7 95.00 High High
Hemolysis 5 94.04 High High
Cv General 3 Under Development 11 92.96 High High
Overdose 4 92.08 High High
Hepatotoxicity 1 88.24 High High
Acute Liver Failure 8 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methemoglobin levels were not above the physiologic normal in the current study, and the results did not show a statistically significant association between higher methemoglobin levels in women with higher estimated nitrate intake from their tap water (Table 7).
methemoglobin Neg (not) Binding (association) of
1) Confidence 0.36 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.08 Pain Relevance 0
However, this MCL does not incorporate a built-in safety factor as it is based on methemoglobin formation in infants exposed to water containing greater than10 mg/L nitrate [9].
methemoglobin Binding (formation) of
2) Confidence 0.34 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.23 Pain Relevance 0
Blood pressure, methemoglobin and blood samples to assess the NO metabolome, including nitrite and nitrate in plasma, whole blood and red blood cells, and the sum of protein and lipid bound NO (S-nitrosothiols) in plasma were collected directly before the infusion and then at 0, 2, 5, 10, 20, 30, 60, 90 minutes and 2, 3, 4, 5, 6, 8, 12, 24 and 48 hours (Figure 6) during sodium nitrite infusion.
methemoglobin Binding (bound) of in Blood
3) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0 Pain Relevance 0.07
The effects of the three vasodilators on Hb were correlated with pH, methemoglobin formation, temperature and incubation time. 3.
methemoglobin Binding (formation) of
4) Confidence 0.28 Published 1992 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 1342232 Disease Relevance 0.09 Pain Relevance 0.09
In addition, the enzyme methemoglobin reductase cannot interact with and efficiently reduce the methemoglobin in individuals who display this form of hemoglobin [6].
methemoglobin Binding (interact) of
5) Confidence 0.23 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2263062 Disease Relevance 0.46 Pain Relevance 0.12
Primaquine alone did not produce any hemotoxicity, while a robust increase was observed in methemoglobin formation and generation of ROIs by primaquine in the presence of human or mouse liver microsomes.
methemoglobin Binding (formation) of in liver
6) Confidence 0.22 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19616568 Disease Relevance 0.17 Pain Relevance 0.07
Methemoglobin formation, real-time generation of reactive oxygen intermediates (ROIs) and depletion of reactive thiols were monitored as multiple biochemical end points for hemotoxicity.
Methemoglobin Binding (formation) of
7) Confidence 0.22 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19616568 Disease Relevance 0.07 Pain Relevance 0
Acquired methemoglobinemia is more common than hereditary causes and occurs when an exogenous substance oxidizes hemoglobin producing methemoglobin at rates 100 to 1000 times greater than it can be metabolized.
methemoglobin Binding (oxidizes) of associated with methemoglobinemia
8) Confidence 0.18 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2263062 Disease Relevance 0.54 Pain Relevance 0.21
Methemoglobin formation and resulting respiratory failure were identified as major problems in intravenously administered acetaminophen intoxication models.
Methemoglobin Binding (formation) of in respiratory associated with paracetamol, respiratory failure and poisoning
9) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2945114 Disease Relevance 1.36 Pain Relevance 0.34
Prolocaine plasma concentrations and methemoglobin formation were both far below toxic levels.
methemoglobin Binding (formation) of in plasma
10) Confidence 0.15 Published 1990 Journal Reg Anaesth Section Abstract Doc Link 2389069 Disease Relevance 0.12 Pain Relevance 0.59
Correlation between their physicochemical properties and their doses for the depletions of ATP, GSH and Hb was performed in comparison with those of the membrane bound enzyme (MBE) inhibiting- and methemoglobin (MHb)-generating drugs.
methemoglobin Binding (bound) of
11) Confidence 0.04 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12913268 Disease Relevance 0.15 Pain Relevance 0.56
M73101 showed no significant pharmacological activities on the blood sugar level, blood coagulation, platelet aggregation, methemoglobin formation and local irritation.
methemoglobin Neg (no) Binding (formation) of in platelet
12) Confidence 0.03 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 317064 Disease Relevance 0.17 Pain Relevance 0.17
Although NAPQI has been proposed as the responsible intermediate in dogs and cats, it lacks chemical or pharmacokinetic characteristics that favor methemoglobin formation.
methemoglobin Binding (formation) of
13) Confidence 0.03 Published 2009 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 20444014 Disease Relevance 0.77 Pain Relevance 0.41

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