INT20210

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Context Info
Confidence 0.79
First Reported 1990
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 69
Total Number 73
Disease Relevance 46.22
Pain Relevance 38.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 21
microglia 6
neurons 5
brain 4
neuronal 3
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 985 100.00 Very High Very High Very High
Nerve growth factor 842 100.00 Very High Very High Very High
opioid receptor 213 100.00 Very High Very High Very High
chemokine 76 100.00 Very High Very High Very High
Inflammatory mediators 61 100.00 Very High Very High Very High
bradykinin 42 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
Serotonin 27 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
Endogenous opioid 77 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1068 100.00 Very High Very High Very High
Cancer 406 99.98 Very High Very High Very High
Melanoma 204 99.84 Very High Very High Very High
Nerve Sheath Neoplasms 22 99.84 Very High Very High Very High
Respiratory Syncytial Virus 81 99.82 Very High Very High Very High
Death 316 99.76 Very High Very High Very High
Eczema 233 99.60 Very High Very High Very High
Pain 684 99.50 Very High Very High Very High
Disease 1550 99.34 Very High Very High Very High
Targeted Disruption 218 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The secretion of glia cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and transforming growth factor-beta (TGF-beta) contributes to the maintenance of epithelial integrity and the secretion of endothelins might be involved in vasoregulation.
Spec (might) Localization (secretion) of nerve growth factor in nerve associated with nerve growth factor
1) Confidence 0.79 Published 2006 Journal Z Gastroenterol Section Abstract Doc Link 16981072 Disease Relevance 0.26 Pain Relevance 0.16
The secretion of glia cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and transforming growth factor-beta (TGF-beta) contributes to the maintenance of epithelial integrity and the secretion of endothelins might be involved in vasoregulation.
Spec (might) Localization (secretion) of NGF in nerve associated with nerve growth factor
2) Confidence 0.79 Published 2006 Journal Z Gastroenterol Section Abstract Doc Link 16981072 Disease Relevance 0.26 Pain Relevance 0.17
The experience with NGF expression in nerve sheath tumors is much more limited, but it seems reasonable to hypothesize that NGF might be secreted by MPNST's.
Localization (secreted) of NGF in nerve associated with nerve sheath neoplasms and nerve growth factor
3) Confidence 0.78 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2291052 Disease Relevance 1.58 Pain Relevance 0.87
In addition, McC10 was used successfully in two-step immunocytochemistry (ICC) for the localization of enkephalin, nerve growth factor (NGF) receptor and paired helical filament-immunoreactive sites in rat brain, rat skin and human brain, respectively, using mouse IgG's and IgM's as primary antibodies.
Localization (localization) of nerve growth factor in brain associated with nerve growth factor and enkephalin
4) Confidence 0.78 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0.15
These data suggest a biological scenario and rationale in which the developing mouse tumor secretes NGF into the circulation, where it circulates in the blood to the salivary glands and binds to NGF receptors expressed by salivary acinar cells, activating a signaling pathway that leads to the upregulation of Egr-1 mRNA and protein levels.
Localization (secretes) of NGF in acinar cells associated with nerve growth factor, salivary gland disease and cancer
5) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.29 Pain Relevance 0.32
Therefore, it is reasonable to propose that NGF secreted by melanoma tumor was transferred through blood and bound to its cognate receptors in the salivary gland, ultimately resulting in the stimulation of multiple TFs expression including Egr-1 (Fig. 6).
Localization (secreted) of NGF in blood associated with nerve growth factor, cancer and melanoma
6) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.24 Pain Relevance 0.40
Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons.
Localization (Neutralization) of nerve growth factor in nerve associated with ganglion cysts, nociception, nerve growth factor and trigeminal ganglion neurons
7) Confidence 0.75 Published 2007 Journal J. Neurosci. Section Title Doc Link 17670966 Disease Relevance 0.65 Pain Relevance 0.69
After capsaicin inhalation, there was an increase in NGF in the patient group (mean increase after provocation: 11.1 pg/mL; 95% CI, 3.1–19.1; p < 0.01) but not among control subjects, who displayed a decrease in NGF (mean decrease after provocation: 3.2 pg/mL; 95% CI, ?
Localization (increase) of NGF associated with nerve growth factor and qutenza
8) Confidence 0.75 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.06 Pain Relevance 0.95
Hypothesizing that a neurochemical alteration takes place in patients with SHR, we measured NGF levels in nasal secretions before and after capsaicin inhalation provocations and related the levels to capsaicin cough sensitivity.
Localization (secretions) of NGF in nasal associated with qutenza, nerve growth factor and cough
9) Confidence 0.75 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.72 Pain Relevance 0.83
Collection of NAL and determination of nerve growth factor.
Localization (determination) of nerve growth factor in nerve associated with nerve growth factor
10) Confidence 0.75 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.54 Pain Relevance 0.48
The results suggest that NGF stimulates the release of endogenous opioids (e.g., dynorphin) from DRG neurons and that prolongation of the APD occurs secondarily by activation of excitatory kappa-opioid receptor functions on these same or nearby cells.
Localization (release) of NGF in DRG associated with action potential, dorsal root ganglion, dynorphin, kappa opioid receptor and endogenous opioid
11) Confidence 0.71 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8083754 Disease Relevance 0.63 Pain Relevance 1.50
NGF is released in the setting of inflammation and can not only function as a chemoattractant for other mast cells, but it can also trigger mast cell degranulation [23].
Localization (released) of NGF in mast cell associated with inflammation
12) Confidence 0.70 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.93 Pain Relevance 0.78
In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?
Localization (application) of NGF in microglia
13) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.61
The results of these studies indicated that substance P and neurokinin A can directly induce nerve growth factor mRNA expression and the secretion of bioactive nerve growth factor protein in both human and murine keratinocytes.
Localization (secretion) of nerve growth factor in keratinocytes associated with nerve growth factor and substance p
14) Confidence 0.67 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710915 Disease Relevance 0 Pain Relevance 0.93
We therefore hypothesize that NGF is secreted into the circulation by the melanoma, circulates to the salivary gland where it activates the receptor-mediated signaling cascade leading to Egr-1 upregulation and induction of specific gene transcription and protein translation.
Localization (secreted) of NGF in salivary gland associated with nerve growth factor and melanoma
15) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.09 Pain Relevance 0.33
Collectively these data suggest that melanoma can produce NGF and is secreted it into the bloodstream.
Localization (secreted) of NGF associated with nerve growth factor and melanoma
16) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.01 Pain Relevance 0.36
NGF-induced release of small quantities of opioids by DRG neurons would be expected to prolong the APD in view of the remarkable sensitivity of these neurons to the excitatory effects of extremely low (fM-nM) concentrations of exogenous opioid agonists.
Localization (release) of NGF in neurons associated with action potential, dorsal root ganglion, mu agonist and opioid
17) Confidence 0.66 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8083754 Disease Relevance 0.63 Pain Relevance 1.54
Nerve growth factor (NGF), which belongs to the neurotrophin family, is mainly produced and released by the basal keratinocytes15-19 and has diverse activity in the skin.
Localization (released) of Nerve growth factor in Nerve associated with nerve growth factor
18) Confidence 0.65 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.98 Pain Relevance 0.50
Nerve growth factor (NGF), which belongs to the neurotrophin family, is mainly produced and released by the basal keratinocytes15-19 and has diverse activity in the skin.
Localization (released) of NGF in Nerve associated with nerve growth factor
19) Confidence 0.65 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.98 Pain Relevance 0.50
Consequently, activated microglia release chemokines like BDNF, NGF, IL-1?
Localization (release) of NGF in microglia associated with chemokine
20) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.63

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