INT202106

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 100.00 Very High Very High Very High
Arthritis 3 99.90 Very High Very High Very High
Inflammatory response 2 86.84 High High
Inflammatory mediators 1 83.16 Quite High
cytokine 8 63.16 Quite High
Osteoarthritis 4 44.40 Quite Low
IPN 1 28.56 Quite Low
agonist 14 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Arthritis 4 99.90 Very High Very High Very High
Disease 6 99.44 Very High Very High Very High
Apoptosis 10 96.44 Very High Very High Very High
Stress 7 69.28 Quite High
Leukemia 4 68.68 Quite High
Lymphatic System Cancer 7 51.12 Quite High
Osteoarthritis 6 44.40 Quite Low
Reperfusion Injury 1 40.60 Quite Low
Cv Unclassified Under Development 1 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in the activation of pro-inflammatory signalling responses such as JNK and p38 MAP kinase in a cell line (clone G) expressing both PAR2 and TNFR1 receptors.
Positive_regulation (activation) of Gene_expression (expressing) of TNFR1 associated with inflammation
1) Confidence 0.22 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.50 Pain Relevance 0.21
In contrast, expression of CD95 (Figure 4D), TNFR1 or NGFR (data not shown) did not promote Trx1 interactions with the cell surface, further strengthening the notion that Trx1 reactivity is a specific property of CD30.
Neg (not) Positive_regulation (promote) of Gene_expression (expression) of TNFR1
2) Confidence 0.13 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0
levels are elevated in arthritis and TNFR55 expression is increased in arthritic disease [44], our future studies will determine whether TNF-?
Positive_regulation (increased) of Gene_expression (expression) of TNFR55 associated with disease and arthritis
3) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779424 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

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