INT20213

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Context Info
Confidence 0.08
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.11
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp11c) plasma membrane (Atp11c)
Atp11c (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 99.06 Very High Very High Very High
Enkephalin 1 86.80 High High
Nerve growth factor 1 85.84 High High
addiction 2 84.16 Quite High
Inflammatory response 4 83.96 Quite High
Arthritis 87 55.56 Quite High
COX2 1 45.16 Quite Low
cytokine 19 16.84 Low Low
rheumatoid arthritis 31 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 60 100.00 Very High Very High Very High
INFLAMMATION 54 99.06 Very High Very High Very High
Targeted Disruption 89 90.24 High High
Autoimmune Disease 4 68.28 Quite High
Congenital Anomalies 3 65.92 Quite High
Embryonic Lethality 4 61.52 Quite High
Arthritis 91 55.56 Quite High
Disease 57 52.00 Quite High
Blister 36 50.00 Quite Low
Neuromyelitis Optica 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: We used confocal microscopy and flow cytometry to evaluate the selectivity and immunopathological consequences of Ig binding to surface epitopes of living target cells expressing aquaporin-4 fused at its cytoplasmic N-terminus with GFP.
Ig Binding (binding) of
1) Confidence 0.08 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
Conversely, complement-driven inflammation may dominate when immune complexes containing Ig-constant regions are poorly bound by FcR or when leuko-cytes must be attracted to an inflammatory site.
Ig Binding (bound) of associated with inflammation
2) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.09 Pain Relevance 0.53
The use of a modified ES cell line exhibiting improved rates of homologous recombination at the Ig?
Ig Binding (recombination) of
3) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1140086 Disease Relevance 0.23 Pain Relevance 0
These results indicate that the Ig?
Ig Binding (indicate) of
4) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1140086 Disease Relevance 0.07 Pain Relevance 0
Intriguingly, PF Ig had a minor effect on Dsg1-?
Ig Binding (Intriguingly) of associated with bullous skin disease
5) Confidence 0.04 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.71 Pain Relevance 0
Epitope specificity of this bi-specific antibody was more clearly determined on immunoblots where McC10 was found to exclusively recognize mouse kappa light chains and display no cross-reactivity with mouse Ig heavy chains nor with kappa light chains from rat or rabbit.
Ig Neg (no) Binding (cross-reactivity) of
6) Confidence 0.02 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0.13

General Comments

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