INT202140

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.58
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
cartilage 1
skeletal muscle 1
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 145 98.24 Very High Very High Very High
cocaine 292 78.48 Quite High
Dopamine 1 70.72 Quite High
Bioavailability 6 61.76 Quite High
Central nervous system 10 38.16 Quite Low
Pain 41 25.40 Quite Low
rheumatoid arthritis 5 15.12 Low Low
Inflammation 53 5.00 Very Low Very Low Very Low
ischemia 20 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 147 98.24 Very High Very High Very High
Inflammatory Bowel Disease 26 94.00 High High
Shock 1 93.88 High High
Stress 58 90.56 High High
Apoptosis 81 87.36 High High
Malignant Neoplastic Disease 1 85.52 High High
Colon Cancer 1 68.16 Quite High
Leukemia 1 67.60 Quite High
Lung Cancer 1 67.20 Quite High
Breast Cancer 3 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Superoxide dismutase (SOD), an enzyme that catalyses the degradation of ROS to oxygen and hydrogen peroxide, was discovered approximately 40 years ago.
Protein_catabolism (degradation) of ROS
1) Confidence 0.28 Published 2008 Journal Colorectal Disease Section Body Doc Link PMC2659364 Disease Relevance 0.36 Pain Relevance 0
In addition, the activity of superoxide dismutase (SOD), a free radical scavenging enzyme that catalyzes the breakdown of ROS to hydrogen peroxide and molecular oxygen, tended to decrease in the skeletal muscle of the CR group (?
Protein_catabolism (breakdown) of ROS in skeletal muscle
2) Confidence 0.24 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.05 Pain Relevance 0
m can disturb intracellular ATP synthesis, generation of reactive oxygen species (ROS), altered mitochondrial redox ratio, translocation of cyto c to the cytosol, and degradation of caspase-3/PARP[9-12].
Protein_catabolism (degradation) of ROS
3) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 1.00 Pain Relevance 0
Redox cycling between norcocaine nitroxide and N-hydroxynorcocaine is responsible for generation of ROS such as superoxide anion and hydrogen peroxide [37,44].
Protein_catabolism (generation) of ROS
4) Confidence 0.19 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.12 Pain Relevance 0.20
defense systems that include ROS degrading molecules (ROS scavengers), such as
Protein_catabolism (degrading) of ROS
5) Confidence 0.17 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.16 Pain Relevance 0.03
defense systems that include ROS degrading molecules (ROS scavengers), such as
Protein_catabolism (degrading) of ROS
6) Confidence 0.17 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.16 Pain Relevance 0.03
However, when ROS are produced in increased amounts like in OA, the antioxidant capacity of cells and tissues can become insufficient to detoxify the ROS, which then contribute to cartilage degradation by inhibiting matrix synthesis, directly degrading matrix molecules, or activating MMPs (reviewed in [53]).
Protein_catabolism (degradation) of ROS in cartilage associated with osteoarthritis
7) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.72 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox