INT20215

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.20
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
radial 1
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 21 92.88 High High
methotrexate 5 89.64 High High
dexamethasone 5 89.44 High High
Potency 2 83.84 Quite High
Inflammation 19 71.84 Quite High
rheumatoid arthritis 38 69.44 Quite High
cINOD 1 68.28 Quite High
Enkephalin 1 38.16 Quite Low
Nerve growth factor 1 37.20 Quite Low
antagonist 7 36.96 Quite Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 92 99.56 Very High Very High Very High
Arthritis 29 92.88 High High
Pressure And Volume Under Development 6 79.28 Quite High
INFLAMMATION 23 71.84 Quite High
Disease 25 69.64 Quite High
Rheumatoid Arthritis 38 69.44 Quite High
Sprains And Strains 8 61.76 Quite High
Infection 36 59.64 Quite High
Cold Sores 4 52.68 Quite High
Coccidiosis 1 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hybrid-hybridoma generated from this fusion expresses and secretes rat Igs of the IgG1 and IgG2a subclasses, as determined by radial immunodiffusion.
Localization (secretes) of IgG2a in radial
1) Confidence 0.78 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0
D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.
Localization (secretion) of IgG2a
2) Confidence 0.43 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.59 Pain Relevance 0.58
Anticollagen IgG2a (regarded as a marker for a Th1 response) was reduced, and there was an increase in IgG1 (regarded as a marker for a Th2 response).
Localization (response) of IgG2a
3) Confidence 0.20 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.59 Pain Relevance 0.10
Covalent linkage of CpG ODN to influenza virus HA resulted in secretion of high levels of IFN- and HA-specific IgG2a antibodies [122] suggesting that crosslinking CpG ODNs to peptides may be an efficient adjuvant method.
Localization (secretion) of IgG2a associated with influenza virus infection
4) Confidence 0.14 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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