INT20216

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Context Info
Confidence 0.80
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 41
Disease Relevance 18.16
Pain Relevance 16.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 6
fibroblast 4
brain 2
neurite 2
stem cells 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 424 100.00 Very High Very High Very High
Inflammation 178 100.00 Very High Very High Very High
cytokine 98 100.00 Very High Very High Very High
qutenza 42 100.00 Very High Very High Very High
bradykinin 25 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Neuropeptide 33 99.98 Very High Very High Very High
Calcitonin gene-related peptide 40 99.88 Very High Very High Very High
Glutamate 78 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 100.00 Very High Very High Very High
Neuropathic Pain 67 99.92 Very High Very High Very High
Mycobacterium Infection 1 99.84 Very High Very High Very High
Cv General 4 Under Development 83 99.36 Very High Very High Very High
Dissociative Disorders 11 99.22 Very High Very High Very High
Injury 201 98.98 Very High Very High Very High
Ganglion Cysts 24 98.52 Very High Very High Very High
Nociception 58 98.44 Very High Very High Very High
Hypoalagesia 2 98.44 Very High Very High Very High
Osteoarthritis 13 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.
Localization (release) of NGF in axilla associated with nerve growth factor
1) Confidence 0.80 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.27 Pain Relevance 0.55
Dexamethasone promotes fibronectin synthesis and suppresses NGF secretion, suggesting that this reagent could be used clinically to reduce pain and promote dental pulp tissue healing.
Localization (secretion) of NGF in dental pulp associated with pain, nerve growth factor and dexamethasone
2) Confidence 0.79 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.24 Pain Relevance 0.71
NGF is released by mastocytes, fibroblasts and other cell types involved in the inflammatory processes.
Localization (released) of NGF in fibroblasts associated with inflammation
3) Confidence 0.79 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.46 Pain Relevance 0.29
Co-localization within a vascular channel of NGF immunoreactivity (E, red) and a CGRP-immunoreactive nerve (F, black, arrow), demonstrated in serial tissue sections from a patient with OA.
Localization (localization) of NGF in nerve associated with nerve growth factor and calcitonin gene-related peptide
4) Confidence 0.76 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.59 Pain Relevance 0.25
Decreased NGF in leprosy skin may explain cutaneous hypoalgesia even with inflammation and rhNGF may restore sensation, as spared nerve fibers show Trk A-staining.
Localization (Decreased) of NGF in nerve associated with inflammation, nerve growth factor, mycobacterium infection, trk a and hypoalgesia
5) Confidence 0.75 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.18 Pain Relevance 0.74
This study demonstrated the presence of NGF and TrkA in specimens collected from degenerative facet joints, suggesting that specific molecules could be used in order to modulate chronic pain in patients with degenerative lumbar spine.
Localization (presence) of NGF in joints associated with facet joint and lasting pain
6) Confidence 0.73 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.67 Pain Relevance 0.52
VEGF, PDGF and NGF were also localized to chondrocytes.
Localization (localized) of NGF in chondrocytes associated with nerve growth factor
7) Confidence 0.71 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.42 Pain Relevance 0.32
In this first study of injured human nerves and sensory ganglia, we quantified and localized endogenous NGF and CNTF in 59 neonate and adult patients with brachial plexus and peripheral nerve injury.
Localization (localized) of NGF in brachial plexus associated with nervous system injury, nerve growth factor and peripheral nerve injury
8) Confidence 0.71 Published 1997 Journal Neuroreport Section Abstract Doc Link 9223080 Disease Relevance 0.59 Pain Relevance 0.56
Nerve growth factor (NGF) and its receptor tyrosine kinase A (TrkA) participate in endocrine pancreas morphogenesis and insulin secretion in vitro.
Localization (secretion) of NGF in Nerve associated with nerve growth factor
9) Confidence 0.70 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279365 Disease Relevance 0.32 Pain Relevance 0.34
Finally, CRIB (cellular replacement by immunoisolatory biocapsule) is an auspicious gene therapeutical approach for human NGF secretion, which has been shown to protect cholinergic neurones from cell death when implanted in the brain.
Localization (secretion) of NGF in brain associated with nerve growth factor and death
10) Confidence 0.70 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 0.61 Pain Relevance 0.36
A CNS-derived, conditionally immortalized, neural progenitor cell line (CINP) was generated to make nerve growth factor (NGF)-secreting cells using a retroviral vector (25).
Localization (secreting) of NGF in neural associated with nerve growth factor and central nervous system
11) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0 Pain Relevance 0.10
Wound PG-E2 and various cytokines peaked early, whereas NGF showed a more delayed release.
Localization (release) of NGF associated with nerve growth factor, injury and cytokine
12) Confidence 0.68 Published 2008 Journal J Pain Section Abstract Doc Link 18394968 Disease Relevance 1.38 Pain Relevance 0.97
In addition, McC10 was used successfully in two-step immunocytochemistry (ICC) for the localization of enkephalin, nerve growth factor (NGF) receptor and paired helical filament-immunoreactive sites in rat brain, rat skin and human brain, respectively, using mouse IgG's and IgM's as primary antibodies.
Localization (localization) of NGF in brain associated with nerve growth factor and enkephalin
13) Confidence 0.68 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0.15
Wound PG-E2 and various cytokines peaked early, whereas NGF showed a more delayed release.
Localization (release) of NGF associated with nerve growth factor, injury and cytokine
14) Confidence 0.68 Published 2008 Journal Journal of visualized experiments : JoVE Section Abstract Doc Link 19078937 Disease Relevance 1.29 Pain Relevance 0.81
in the modulation of neurotrophin expression in the IVD comes from studies by Abe and colleagues, who demonstrated an increase in NGF gene expression and protein secretion after NP cells (cultured in monolayer) were treated with IL-1?
Localization (secretion) of NGF associated with nerve growth factor
15) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.35 Pain Relevance 0.42
were shown to increase NGF synthesis and release [27].
Localization (release) of NGF associated with nerve growth factor
16) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.37 Pain Relevance 0.48
m, or, for CGRP- and NGF-co-localization, 20??
Localization (localization) of NGF associated with nerve growth factor and calcitonin gene-related peptide
17) Confidence 0.67 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0 Pain Relevance 0.27
Whole antler extracts promote neurite outgrowth in vitro [14] and we have shown that velvet -but not mesenchyme- secretes nerve growth factor (NGF) and other molecules that strongly promote neurite outgrowth in vitro [9].
Localization (secretes) of nerve growth factor in neurite associated with nerve growth factor
18) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.20
Whole antler extracts promote neurite outgrowth in vitro [14] and we have shown that velvet -but not mesenchyme- secretes nerve growth factor (NGF) and other molecules that strongly promote neurite outgrowth in vitro [9].
Localization (secretes) of NGF in neurite associated with nerve growth factor
19) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.20
For example, human neural stem cells constitutively secrete nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor (GDNF) that promote growth of injured axons following spinal cord injury [1].
Localization (secrete) of NGF in stem cells associated with nerve growth factor and spinal cord
20) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.42 Pain Relevance 0.25

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