INT202174

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
neutrophils 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 139 100.00 Very High Very High Very High
Inflammatory mediators 4 100.00 Very High Very High Very High
chemokine 42 98.98 Very High Very High Very High
Inflammation 22 86.76 High High
cytokine 8 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 139 100.00 Very High Very High Very High
INFLAMMATION 27 100.00 Very High Very High Very High
Disease 38 90.72 High High
Infection 2 81.04 Quite High
Neutrophil Disorders 1 62.24 Quite High
Cancer 5 54.64 Quite High
Necrosis 4 54.16 Quite High
Urological Neuroanatomy 7 12.16 Low Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Cryopyrin-associated Periodic Syndromes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes downregulated in JRA neutrophils relative to healthy controls (Table 2) included the immune and inflammatory mediators CCL3, CCL4, CCL5, IL-1B, COX-2, MHC-II DR-?
Negative_regulation (downregulated) of CCL3 in neutrophils associated with inflammatory mediators and rheumatoid arthritis
1) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779452 Disease Relevance 0.98 Pain Relevance 0.44
SF PMN from patients with RA exhibit a characteristic chemokine expression pattern resembling the upregulation of CCL3, CCL18, CXCL8 and CXCL10 mRNAs and the downregulation of CCL21 mRNA.
Negative_regulation (downregulation) of CCL3 associated with chemokine and rheumatoid arthritis
2) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.79 Pain Relevance 0.45

General Comments

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