INT202177

Context Info Confidence 0.22 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.21

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12) cytoplasm (S100A12)

S100A12 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 90 95.32 Inflammatory mediators 2 60.08 Inflammation 9 5.00 cytokine 2 5.00 corticosteroid 1 5.00 methotrexate 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 90 95.32 INFLAMMATION 11 59.68 Disease 33 5.00 Urological Neuroanatomy 7 5.00 Congenital Anomalies 3 5.00 Cancer 3 5.00 Necrosis 2 5.00 Synovitis 2 5.00 Cryopyrin-associated Periodic Syndromes 2 5.00 Hyperplasia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This process, like S100 protein levels, is likely tied to enhanced secretory activity, in that myeloperoxidase, like S100 proteins, is normally stored in intracellular granules and not released in control cells, although surface expression is seen for some polyarticular JRA neturophils.

Negative_regulation (tied) of Gene_expression (levels) of S100 protein associated with rheumatoid arthritis

1) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779452 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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