INT202183

Context Info Confidence 0.11 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.25 Pain Relevance 0.21

signal transduction (PLAU, PLAUR) extracellular region (PLAU, PLAUR) plasma membrane (PLAU, PLAUR) peptidase activity (PLAU) extracellular space (PLAU) enzyme binding (PLAUR)

Anatomy Link Frequency extracellular matrix 2 PLAU (Homo sapiens) PLAUR (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 1 94.56 Inflammation 5 87.84 cytokine 1 84.24 metalloproteinase 2 5.00 COX2 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 29 98.92 Wound Healing 5 96.60 Adhesions 1 96.32 Metastasis 2 93.88 INFLAMMATION 5 87.84 Injury 5 65.20 Breast Cancer 15 54.08 Carcinoma 1 41.76 Apoptosis 1 27.76 Aggression 1 7.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, uPA, uPAR and its inhibitor PAI-1 are responsible for the degradation and remodeling of the extracellular matrix, and are further involved in angiogenesis, cell adhesion and migration necessary for tumor cell invasion and metastasis [31,32].

uPA Regulation (responsible) of Protein_catabolism (degradation) of uPAR in extracellular matrix associated with cancer, metastasis and adhesions

1) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 1.25 Pain Relevance 0.21

General Comments

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