INT202189

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.80
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
myometrium 2
uterus 1
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 12 97.76 Very High Very High Very High
Inflammation 9 85.20 High High
cytokine 4 84.16 Quite High
dexamethasone 2 81.00 Quite High
metalloproteinase 2 21.08 Low Low
COX2 1 15.08 Low Low
chemokine 1 10.48 Low Low
agonist 23 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Dismenorea 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 30 96.96 Very High Very High Very High
INFLAMMATION 9 85.20 High High
Breast Cancer 15 82.44 Quite High
Injury 5 68.88 Quite High
Wound Healing 5 67.52 Quite High
Targeted Disruption 3 67.52 Quite High
Anencephaly 6 26.00 Quite Low
Stress 2 22.72 Low Low
Pre-term Labor 37 5.92 Low Low
Premature Birth 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not known what brings about the changes in PGR expression in the uterus at the time of parturition; however it is possible that these are mediated by changes in histone acetylase activity which is required for PGR transcription.
Transcription (transcription) of PGR in uterus
1) Confidence 0.51 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.05 Pain Relevance 0.07
A new approach to our understanding of progesterone function has followed the description of membrane-bound isoforms of the PGR (mPGR) resembling GPCRs in human myometrium [29,30].
Transcription (description) of PGR in myometrium
2) Confidence 0.49 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.07 Pain Relevance 0
A new approach to our understanding of progesterone function has followed the description of membrane-bound isoforms of the PGR (mPGR) resembling GPCRs in human myometrium [29,30].
Transcription (description) of mPGR in myometrium
3) Confidence 0.49 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.07 Pain Relevance 0
Even in the cases where GEPs of a CB and ST did not agglomerate, the expression levels of the ER and progesterone receptor as well as ERBB2 measured in the CB were also representative for the whole tumor.
Transcription (levels) of progesterone receptor associated with cancer
4) Confidence 0.13 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.53 Pain Relevance 0.03
It is the expression of PR-A mRNA, relative to PR-B mRNA that leads to functional withdrawal of progesterone.65 In vitro studies in mice demonstrate increased transcriptional activities of NF-??
Transcription (expression) of PR associated with withdrawal
5) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.09 Pain Relevance 0.30

General Comments

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