INT202190

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.19
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CBS) lyase activity (CBS) enzyme binding (CBS)
cytoplasm (CBS) cytosol (CBS) nucleolus (CBS)
Anatomy Link Frequency
plasma 1
cerebrospinal fluid 1
brain 1
Chlamydospores 1
CBS (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 83 93.12 High High
Inflammation 36 91.56 High High
Hippocampus 13 88.16 High High
Cannabinoid 45 86.88 High High
Neurotransmitter 4 81.84 Quite High
cytokine 17 80.72 Quite High
Endocannabinoid 41 75.00 Quite High
long-term potentiation 7 66.76 Quite High
GABAergic 13 56.64 Quite High
metalloproteinase 4 50.64 Quite High
Disease Link Frequency Relevance Heat
Disease 174 99.92 Very High Very High Very High
Cancer 58 98.20 Very High Very High Very High
Cognitive Disorder 75 98.00 Very High Very High Very High
Cicatrix 8 94.32 High High
INFLAMMATION 36 91.56 High High
Ulcers 1 91.36 High High
Breast Cancer 30 90.80 High High
Disease Progression 3 80.16 Quite High
Injury 18 71.72 Quite High
Schizophrenia 18 51.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4, the expression levels of PAI-1 and COX-2 measured in the independent STs without CB were found to be very similar to the levels detected in CBs and significantly different from those detected in STs after CB.
Gene_expression (detected) of CBs
1) Confidence 0.32 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.45 Pain Relevance 0.06
Our data demonstrate that the quantitative expression levels of 60 genes detected in CBs were highly comparable to their paired STs in 17 out of the 21 cases investigated.
Gene_expression (expression) of CBs
2) Confidence 0.28 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.54 Pain Relevance 0
Chlamydospores absent
[present in CBS
109797]. 
Neg (absent) Gene_expression ([present) of CBS in Chlamydospores
3) Confidence 0.23 Published 2008 Journal Studies in Mycology Section Body Doc Link PMC2610306 Disease Relevance 0.27 Pain Relevance 0
In plasma, the mean circulating levels of 2-AG in our AD and controls samples were nearly 60 times those detected in the CSF of subjects undergoing cognitive testing described above (where AEA was not detected at all), most likely representing a greater proliferation of immune competent cells producing eCBs in plasma. eCBs may also exert an influence over cognition only in the context of dramatic overproduction, as may be the case in neuroinflammatory diseases such as AD.
Gene_expression (producing) of eCBs in plasma associated with cognitive disorder and disease
4) Confidence 0.02 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2631501 Disease Relevance 1.05 Pain Relevance 0.27
Detectable eCBs in cerebrospinal fluid (CSF) had no relationship to cognitive performance in healthy controls at risk for AD.
Gene_expression (Detectable) of eCBs in cerebrospinal fluid associated with cognitive disorder and disease
5) Confidence 0.02 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2631501 Disease Relevance 0.87 Pain Relevance 0.12
In particular, the eCBs 2-AG and AEA have been shown to be synthesized on demand [18, 46] by the postsynaptic cell in response to either physiological and/or pathological stimuli in several brain regions.
Gene_expression (synthesized) of eCBs in brain
6) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0 Pain Relevance 0.31
The relationship between eCBs and C-reactive protein might be investigated in samples with elevated levels of C-reactive protein, as there may be correlations in situations of systemic immune response.
Gene_expression (eCBs) of eCBs
7) Confidence 0.01 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2631501 Disease Relevance 1.01 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox