INT202193

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.02
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt19)
Anatomy Link Frequency
liver 2
bone marrow 2
hepatocytes 1
bowel 1
mononuclear cells 1
Krt19 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 15 99.80 Very High Very High Very High
Central nervous system 240 99.04 Very High Very High Very High
Paracetamol 20 87.68 High High
Spinal cord 6 87.48 High High
fibrosis 40 76.80 Quite High
palliative 3 40.68 Quite Low
alcohol 15 5.00 Very Low Very Low Very Low
Bile 15 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 5 99.80 Very High Very High Very High
Cancer 109 98.60 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 30 98.00 Very High Very High Very High
Breast Cancer 132 97.02 Very High Very High Very High
Injury 35 96.28 Very High Very High Very High
Recurrence 113 93.12 High High
Acute Liver Failure 45 91.64 High High
Apoptosis 115 91.12 High High
Neurodegenerative Disease 10 89.48 High High
Biliary Liver Cirrhosis 10 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the detection of cytokeratin 19 (CK-19) and of mRNA-positive circulating tumor cells (CTCs) in the peripheral blood and the bone marrow of patients with breast cancer was correlated with increased incidence of relapse in several studies [16,17].
Gene_expression (detection) of cytokeratin 19 in bone marrow associated with cancer, breast cancer and recurrence
1) Confidence 0.45 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.77 Pain Relevance 0.30
Peripheral blood mononuclear cells were prospectively obtained from patients with either early breast cancer (stage I and stage II) or advanced breast cancer (stage III and stage IV) before the initiation of any chemotherapy, in order to identify CTCs that express the CK-19 mRNA-positive cells.
Gene_expression (express) of CK-19 in mononuclear cells associated with breast cancer and advanced or metastatic breast cancer
2) Confidence 0.45 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.81 Pain Relevance 0.24
Furthermore, the detection of cytokeratin 19 (CK-19) and of mRNA-positive circulating tumor cells (CTCs) in the peripheral blood and the bone marrow of patients with breast cancer was correlated with increased incidence of relapse in several studies [16,17].
Gene_expression (detection) of CK-19 in bone marrow associated with cancer, breast cancer and recurrence
3) Confidence 0.45 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.78 Pain Relevance 0.30
Adult hepatocytes contain K8 and K18 as their only cytoplasmic IF pair, whereas cholangiocytes express K7 and K19 in addition.
Gene_expression (express) of K19 in hepatocytes
4) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 0.88 Pain Relevance 0.04
However, one important caveat is the fact, that K8/K18/K19 are expressed in most simple epithelial cells and are therefore not liver-specific (Moll et al. 1982; Ku et al. 1999).
Gene_expression (expressed) of K19 in liver
5) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.31 Pain Relevance 0
K8/K18/K19 are promising serological markers based on their high abundance (approximately 0.3% of total liver protein) and intracellular localization under basal conditions with release into blood upon liver injury (Omary et al. 2002; Ku et al. 2007).
Gene_expression (promising) of K19 in liver associated with injury
6) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.20 Pain Relevance 0
For example, “simple” (i.e., single layered) epithelia, as found in digestive organs, express K8 together with variable levels of K7, K18, K19, and K20 depending on the tissue (Moll et al. 1982; Ku et al. 1999; Coulombe and Omary 2002; Ku et al. 2007).
Gene_expression (levels) of K19
7) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.05 Pain Relevance 0
Up to date, only one published study analyzed the polymorphisms in K19 gene and found no association between K19 variants and inflammatory bowel disease (Tao et al. 2007).
Gene_expression (variants) of K19 in bowel associated with inflammation
8) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.21 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox