INT202194

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 13.99
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt19)
Anatomy Link Frequency
bone marrow 3
CNS 1
mononuclear cells 1
Krt19 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 960 99.34 Very High Very High Very High
Spinal cord 24 87.48 High High
palliative 12 40.68 Quite Low
intrathecal 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 432 99.50 Very High Very High Very High
Cancer 396 99.40 Very High Very High Very High
Disease 276 99.40 Very High Very High Very High
Metastasis 612 98.20 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 120 98.00 Very High Very High Very High
Disease Progression 72 97.90 Very High Very High Very High
Breast Cancer 528 97.02 Very High Very High Very High
Solid Tumor 168 93.72 High High
Death 12 92.84 High High
Malignant Neoplastic Disease 12 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding was not surprising since the detection of CK-19 mRNA-positive tumor cells in the peripheral blood [17,24] or in the bone marrow [25,26] represents an independent predictive and prognostic factor for early clinical relapse and death from the disease.
Transcription (detection) of CK-19 in bone marrow associated with cancer, disease, death and recurrence
1) Confidence 0.54 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.61 Pain Relevance 0.07
A quantitative real-time RT-PCR assay was used for the detection of CK-19 mRNA-positive CTCs, as previously described [16,17].
Transcription (detection) of CK-19
2) Confidence 0.54 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.72 Pain Relevance 0.21
Moreover, our observation that the detection of CK-19 mRNA-positive CTCs was associated with an increased risk of CNS involvement in patients with breast cancer further support the hypothesis.
Transcription (detection) of CK-19 associated with breast cancer and central nervous system
3) Confidence 0.54 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.59 Pain Relevance 0.10
Peripheral blood mononuclear cells were prospectively obtained from patients with either early breast cancer (stage I and stage II) or advanced breast cancer (stage III and stage IV) before the initiation of any chemotherapy, in order to identify CTCs that express the CK-19 mRNA-positive cells.
Transcription (express) of CK-19 in mononuclear cells associated with breast cancer and advanced or metastatic breast cancer
4) Confidence 0.52 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.81 Pain Relevance 0.24
Furthermore, the detection of cytokeratin 19 (CK-19) and of mRNA-positive circulating tumor cells (CTCs) in the peripheral blood and the bone marrow of patients with breast cancer was correlated with increased incidence of relapse in several studies [16,17].
Transcription (detection) of cytokeratin 19 in bone marrow associated with cancer, breast cancer and recurrence
5) Confidence 0.52 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.77 Pain Relevance 0.30
Furthermore, the detection of cytokeratin 19 (CK-19) and of mRNA-positive circulating tumor cells (CTCs) in the peripheral blood and the bone marrow of patients with breast cancer was correlated with increased incidence of relapse in several studies [16,17].
Transcription (detection) of CK-19 in bone marrow associated with cancer, breast cancer and recurrence
6) Confidence 0.52 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.78 Pain Relevance 0.30
We evaluated the presence of CK-19 mRNA-positive CTCs in association with CNS relapse.
Transcription (presence) of CK-19 associated with central nervous system and recurrence
7) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 0.70 Pain Relevance 0.21
Similarly, the multivariate analysis of the different parameters performed in the 40 patients in whom CNS relapse was the only manifestation of disease progression revealed the same predictive factors for CNS relapse (stage of the disease: odds ratio, 0.28 P < 0.001; detection of CK-19 mRNA-positive CTCs: odds ratio, 8.97; P < 0.001; HER2/neu status: odds ratio, 30.42; P < 0.0001).
Transcription (detection) of CK-19 associated with central nervous system, disease, disease progression and recurrence
8) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.20 Pain Relevance 0.20
Multivariate analysis revealed that the stage of disease (odds ratio, 0.23; 95% confidence interval, 0.007–0.23; P = 0.0001), the HER2/neu status (odds ratio, 29.4; 95% confidence interval, 7.51–101.21; P = 0.0001) and the presence of CK-19 mRNA-positive CTCs (odds ratio, 8.31; 95% confidence interval, 3.97–12.84; P = 0.001) were independent predictive factors for CNS relapse.


Transcription (presence) of CK-19 in CNS associated with central nervous system, disease and recurrence
9) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Abstract Doc Link PMC1779464 Disease Relevance 1.41 Pain Relevance 0.23
The incidence of CNS relapse in correlation with the detection of CK-19 mRNA-positive CTCs will be prospectively evaluated in this ongoing study.


Transcription (detection) of CK-19 associated with central nervous system and recurrence
10) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.47 Pain Relevance 0.26
The multivariate analysis, however, demonstrated that the stage of the disease, the HER2/neu status (grade 2+ or grade 3+ by immunohistochemistry) and the presence of CK-19 mRNA-positive CTCs represent independent predictive factors for CNS relapse.
Transcription (presence) of CK-19 associated with central nervous system, disease and recurrence
11) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.70 Pain Relevance 0.20
Table 5 demonstrates that the stage of disease (odds ratio, 0.23; P < 0.0001), the detection of CK-19 mRNA-positive CTCs (odds ratio, 8.31; P = 0.001) and the HER2/neu status (odds ratio, 29.41; P < 0.0001) emerged as independent predictive factors for CNS relapse.
Transcription (detection) of CK-19 associated with central nervous system, disease and recurrence
12) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779464 Disease Relevance 1.24 Pain Relevance 0.27

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